Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00282 Pyridoxal-dependent decarboxylase conserved domain |
Function |
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. |
Biological Process |
GO:0006520 cellular amino acid metabolic process GO:0006576 cellular biogenic amine metabolic process GO:0006584 catecholamine metabolic process GO:0006586 indolalkylamine metabolic process GO:0006836 neurotransmitter transport GO:0007568 aging GO:0007623 circadian rhythm GO:0009308 amine metabolic process GO:0009309 amine biosynthetic process GO:0009404 toxin metabolic process GO:0009636 response to toxic substance GO:0009712 catechol-containing compound metabolic process GO:0009713 catechol-containing compound biosynthetic process GO:0009820 alkaloid metabolic process GO:0010259 multicellular organism aging GO:0015837 amine transport GO:0015842 aminergic neurotransmitter loading into synaptic vesicle GO:0017085 response to insecticide GO:0018958 phenol-containing compound metabolic process GO:0019748 secondary metabolic process GO:0033076 isoquinoline alkaloid metabolic process GO:0035690 cellular response to drug GO:0042401 cellular biogenic amine biosynthetic process GO:0042416 dopamine biosynthetic process GO:0042417 dopamine metabolic process GO:0042423 catecholamine biosynthetic process GO:0042427 serotonin biosynthetic process GO:0042428 serotonin metabolic process GO:0042430 indole-containing compound metabolic process GO:0042435 indole-containing compound biosynthetic process GO:0042493 response to drug GO:0043279 response to alkaloid GO:0044106 cellular amine metabolic process GO:0046189 phenol-containing compound biosynthetic process GO:0046219 indolalkylamine biosynthetic process GO:0046684 response to pyrethroid GO:0048511 rhythmic process GO:0052314 phytoalexin metabolic process GO:0071312 cellular response to alkaloid GO:0071417 cellular response to organonitrogen compound GO:0098700 neurotransmitter loading into synaptic vesicle GO:0099504 synaptic vesicle cycle GO:1901160 primary amino compound metabolic process GO:1901162 primary amino compound biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process |
Molecular Function |
GO:0004058 aromatic-L-amino-acid decarboxylase activity GO:0016597 amino acid binding GO:0016829 lyase activity GO:0016830 carbon-carbon lyase activity GO:0016831 carboxy-lyase activity GO:0030170 pyridoxal phosphate binding GO:0031406 carboxylic acid binding GO:0036468 L-dopa decarboxylase activity GO:0043168 anion binding GO:0048037 cofactor binding |
Cellular Component |
GO:0008021 synaptic vesicle GO:0030133 transport vesicle GO:0030424 axon GO:0043025 neuronal cell body GO:0044297 cell body GO:0070382 exocytic vesicle GO:0098793 presynapse GO:0099503 secretory vesicle |
KEGG |
hsa04726 Serotonergic synapse hsa04728 Dopaminergic synapse hsa00340 Histidine metabolism hsa00350 Tyrosine metabolism hsa00360 Phenylalanine metabolism hsa00380 Tryptophan metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-209776: Amine-derived hormones R-HSA-209905: Catecholamine biosynthesis R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-209931: Serotonin and melatonin biosynthesis |
Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DDC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DDC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DDC in various data sets.
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Points in the above scatter plot represent the mutation difference of DDC in various data sets.
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Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DDC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DDC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DDC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DDC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DDC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DDC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DDC |
Name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Aliases | AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase |
Chromosomal Location | 7p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DDC collected from DrugBank database. |
Details on drugs targeting DDC.
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