Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol |
Domain |
PF09668 Aspartyl protease PF00240 Ubiquitin family |
Function |
Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). |
Biological Process | - |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004190 aspartic-type endopeptidase activity GO:0070001 aspartic-type peptidase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DDI2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DDI2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DDI2 in various data sets.
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Points in the above scatter plot represent the mutation difference of DDI2 in various data sets.
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Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DDI2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DDI2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DDI2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DDI2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DDI2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DDI2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DDI2 |
Name | DNA-damage inducible 1 homolog 2 |
Aliases | MGC14844; DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae); DNA-damage inducible 1 homolog 2 (S. cere ...... |
Chromosomal Location | 1p36.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DDI2 collected from DrugBank database. |
There is no record. |