Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. |
Domain |
PF07716 Basic region leucine zipper |
Function |
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0001955 blood vessel maturation GO:0003002 regionalization GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006983 ER overload response GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0007050 cell cycle arrest GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007389 pattern specification process GO:0009299 mRNA transcription GO:0009798 axis specification GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0009953 dorsal/ventral pattern formation GO:0009991 response to extracellular stimulus GO:0010498 proteasomal protein catabolic process GO:0016055 Wnt signaling pathway GO:0021700 developmental maturation GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030968 endoplasmic reticulum unfolded protein response GO:0031667 response to nutrient levels GO:0032637 interleukin-8 production GO:0032677 regulation of interleukin-8 production GO:0032757 positive regulation of interleukin-8 production GO:0032792 negative regulation of CREB transcription factor activity GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036499 PERK-mediated unfolded protein response GO:0036500 ATF6-mediated unfolded protein response GO:0042594 response to starvation GO:0042692 muscle cell differentiation GO:0042789 mRNA transcription from RNA polymerase II promoter GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043392 negative regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043491 protein kinase B signaling GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0044324 regulation of transcription involved in anterior/posterior axis specification GO:0045444 fat cell differentiation GO:0045445 myoblast differentiation GO:0045454 cell redox homeostasis GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045661 regulation of myoblast differentiation GO:0045662 negative regulation of myoblast differentiation GO:0045786 negative regulation of cell cycle GO:0048262 determination of dorsal/ventral asymmetry GO:0048263 determination of dorsal identity GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051402 neuron apoptotic process GO:0051480 regulation of cytosolic calcium ion concentration GO:0051896 regulation of protein kinase B signaling GO:0051898 negative regulation of protein kinase B signaling GO:0055074 calcium ion homeostasis GO:0060070 canonical Wnt signaling pathway GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060828 regulation of canonical Wnt signaling pathway GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0070997 neuron death GO:0071216 cellular response to biotic stimulus GO:0071695 anatomical structure maturation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0097193 intrinsic apoptotic signaling pathway GO:0097553 calcium ion transmembrane import into cytosol GO:0198738 cell-cell signaling by wnt GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902656 calcium ion import into cytosol GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:2000015 regulation of determination of dorsal identity GO:2000016 negative regulation of determination of dorsal identity GO:2000021 regulation of ion homeostasis GO:2000677 regulation of transcription regulatory region DNA binding GO:2000678 negative regulation of transcription regulatory region DNA binding GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003714 transcription corepressor activity GO:0008134 transcription factor binding GO:0008140 cAMP response element binding protein binding GO:0030275 LRR domain binding GO:0043522 leucine zipper domain binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0005667 transcription factor complex GO:0005770 late endosome GO:0032993 protein-DNA complex GO:0035976 transcription factor AP-1 complex GO:0036488 CHOP-C/EBP complex GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex GO:1990617 CHOP-ATF4 complex GO:1990622 CHOP-ATF3 complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04141 Protein processing in endoplasmic reticulum hsa04210 Apoptosis |
Reactome |
R-HSA-380994: ATF4 activates genes R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones R-HSA-392499: Metabolism of proteins R-HSA-381042: PERK regulates gene expression R-HSA-381119: Unfolded Protein Response (UPR) |
Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DDIT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DDIT3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DDIT3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DDIT3 in various data sets.
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There is no record. |
Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DDIT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DDIT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DDIT3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DDIT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DDIT3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DDIT3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DDIT3 |
Name | DNA-damage-inducible transcript 3 |
Aliases | CHOP10; GADD153; CHOP; C/EBP zeta; CHOP-10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; c/EBP ...... |
Chromosomal Location | 12q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DDIT3 collected from DrugBank database. |
There is no record. |