Browse DEFA1B

Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00323 Mammalian defensin
PF00879 Defensin propeptide
Function

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

> Gene Ontology
 
Biological Process GO:0001906 cell killing
GO:0002227 innate immune response in mucosa
GO:0002251 organ or tissue specific immune response
GO:0002385 mucosal immune response
GO:0006959 humoral immune response
GO:0009615 response to virus
GO:0009620 response to fungus
GO:0009755 hormone-mediated signaling pathway
GO:0019730 antimicrobial humoral response
GO:0019731 antibacterial humoral response
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0031640 killing of cells of other organism
GO:0035821 modification of morphology or physiology of other organism
GO:0042742 defense response to bacterium
GO:0043401 steroid hormone mediated signaling pathway
GO:0044364 disruption of cells of other organism
GO:0048545 response to steroid hormone
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0098542 defense response to other organism
Molecular Function -
Cellular Component GO:0005766 primary lysosome
GO:0005775 vacuolar lumen
GO:0005796 Golgi lumen
GO:0030141 secretory granule
GO:0031983 vesicle lumen
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0042582 azurophil granule
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DEFA1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DEFA1B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DEFA1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-3.2910.00729
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-3.2260.0835
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-3.3680.112
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2670.782
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.7160.642
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.2160.488
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0510.484
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DEFA1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DEFA1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DEFA1B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DEFA1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DEFA1B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DEFA1B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDEFA1B
Namedefensin, alpha 1B
Aliases
Chromosomal Location8p23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DEFA1B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.