Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00323 Mammalian defensin PF00879 Defensin propeptide |
Function |
Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. |
Biological Process |
GO:0001906 cell killing GO:0002227 innate immune response in mucosa GO:0002251 organ or tissue specific immune response GO:0002385 mucosal immune response GO:0006959 humoral immune response GO:0009615 response to virus GO:0009620 response to fungus GO:0009755 hormone-mediated signaling pathway GO:0019730 antimicrobial humoral response GO:0019731 antibacterial humoral response GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031640 killing of cells of other organism GO:0035821 modification of morphology or physiology of other organism GO:0042742 defense response to bacterium GO:0043401 steroid hormone mediated signaling pathway GO:0044364 disruption of cells of other organism GO:0048545 response to steroid hormone GO:0050830 defense response to Gram-positive bacterium GO:0050832 defense response to fungus GO:0051607 defense response to virus GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0098542 defense response to other organism |
Molecular Function | - |
Cellular Component |
GO:0005766 primary lysosome GO:0005775 vacuolar lumen GO:0005796 Golgi lumen GO:0030141 secretory granule GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0035578 azurophil granule lumen GO:0042582 azurophil granule GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-1462054: Alpha-defensins R-HSA-6803157: Antimicrobial peptides R-HSA-1461973: Defensins R-HSA-168256: Immune System R-HSA-168249: Innate Immune System |
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DEFA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of DEFA3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DEFA3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of DEFA3 in various data sets.
|
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DEFA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DEFA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DEFA3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DEFA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DEFA3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DEFA3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DEFA3 |
Name | defensin, alpha 3, neutrophil-specific |
Aliases | HNP-3; HNP3; HP-3; defensin 3, neutrophil-specific; neutrophil peptide 3; Defensin, alpha 3; Neutrophil defe ...... |
Chromosomal Location | 8p23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DEFA3 collected from DrugBank database. |
There is no record. |