Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol Cytoplasmic vesicle, clathrin-coated vesicle |
Domain |
PF03455 dDENN domain PF02141 DENN (AEX-3) domain PF03456 uDENN domain |
Function |
Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
Biological Process | - |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0017112 Rab guanyl-nucleotide exchange factor activity |
Cellular Component |
GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle |
KEGG | - |
Reactome |
R-HSA-199991: Membrane Trafficking R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DENND1C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of DENND1C in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DENND1C in various data sets.
|
Points in the above scatter plot represent the mutation difference of DENND1C in various data sets.
|
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DENND1C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DENND1C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DENND1C. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DENND1C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DENND1C expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DENND1C and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DENND1C |
Name | DENN/MADD domain containing 1C |
Aliases | FLJ22757; connecdenn 3; FAM31C; family with sequence similarity 31, member C; Protein FAM31C; DENN domain-co ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DENND1C collected from DrugBank database. |
There is no record. |