Summary | |
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Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. |
Domain |
PF12796 Ankyrin repeats (3 copies) PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) PF00609 Diacylglycerol kinase accessory domain PF00781 Diacylglycerol kinase catalytic domain |
Function |
- |
Biological Process |
GO:0001505 regulation of neurotransmitter levels GO:0006836 neurotransmitter transport GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007265 Ras protein signal transduction GO:0007269 neurotransmitter secretion GO:0007270 neuron-neuron synaptic transmission GO:0007596 blood coagulation GO:0007599 hemostasis GO:0007611 learning or memory GO:0007612 learning GO:0023061 signal release GO:0030168 platelet activation GO:0030258 lipid modification GO:0034260 negative regulation of GTPase activity GO:0035249 synaptic transmission, glutamatergic GO:0042391 regulation of membrane potential GO:0044708 single-organism behavior GO:0046578 regulation of Ras protein signal transduction GO:0046579 positive regulation of Ras protein signal transduction GO:0046834 lipid phosphorylation GO:0046958 nonassociative learning GO:0046959 habituation GO:0048167 regulation of synaptic plasticity GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050890 cognition GO:0051056 regulation of small GTPase mediated signal transduction GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0051346 negative regulation of hydrolase activity GO:0051966 regulation of synaptic transmission, glutamatergic GO:0060078 regulation of postsynaptic membrane potential GO:0060079 excitatory postsynaptic potential GO:0060292 long term synaptic depression GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099565 chemical synaptic transmission, postsynaptic GO:0099643 signal release from synapse GO:1900452 regulation of long term synaptic depression |
Molecular Function |
GO:0004143 diacylglycerol kinase activity GO:0004857 enzyme inhibitor activity GO:0005095 GTPase inhibitor activity GO:0017016 Ras GTPase binding GO:0030695 GTPase regulator activity GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0008021 synaptic vesicle GO:0030133 transport vesicle GO:0030424 axon GO:0030425 dendrite GO:0032045 guanyl-nucleotide exchange factor complex GO:0033267 axon part GO:0043025 neuronal cell body GO:0043197 dendritic spine GO:0043679 axon terminus GO:0044297 cell body GO:0044306 neuron projection terminus GO:0044309 neuron spine GO:0048786 presynaptic active zone GO:0060076 excitatory synapse GO:0070382 exocytic vesicle GO:0097060 synaptic membrane GO:0098793 presynapse GO:0098794 postsynapse GO:0099503 secretory vesicle |
KEGG |
hsa04070 Phosphatidylinositol signaling system hsa00561 Glycerolipid metabolism hsa00564 Glycerophospholipid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-114508: Effects of PIP2 hydrolysis R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DGKI and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DGKI in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DGKI in various data sets.
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Points in the above scatter plot represent the mutation difference of DGKI in various data sets.
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Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DGKI. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DGKI. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DGKI. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DGKI. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DGKI expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DGKI and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DGKI |
Name | diacylglycerol kinase, iota |
Aliases | DGK-IOTA; DAG kinase iota; diglyceride kinase iota; Diacylglycerol kinase iota |
Chromosomal Location | 7q32.3-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DGKI collected from DrugBank database. |
There is no record. |