Summary | |
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Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Cell membrane |
Domain |
PF12796 Ankyrin repeats (3 copies) PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) PF00609 Diacylglycerol kinase accessory domain PF00781 Diacylglycerol kinase catalytic domain |
Function |
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. |
Biological Process |
GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007596 blood coagulation GO:0007599 hemostasis GO:0030168 platelet activation GO:0030258 lipid modification GO:0046339 diacylglycerol metabolic process GO:0046486 glycerolipid metabolic process GO:0046834 lipid phosphorylation GO:0050817 coagulation GO:0050878 regulation of body fluid levels |
Molecular Function |
GO:0004143 diacylglycerol kinase activity |
Cellular Component |
GO:0030027 lamellipodium GO:0031252 cell leading edge |
KEGG |
hsa04070 Phosphatidylinositol signaling system hsa00561 Glycerolipid metabolism hsa00564 Glycerophospholipid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-114508: Effects of PIP2 hydrolysis R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DGKZ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DGKZ in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DGKZ in various data sets.
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Points in the above scatter plot represent the mutation difference of DGKZ in various data sets.
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Summary | |
---|---|
Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DGKZ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DGKZ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DGKZ. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DGKZ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DGKZ expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DGKZ and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DGKZ |
Name | diacylglycerol kinase, zeta |
Aliases | hDGKzeta; DGK-ZETA; diacylglycerol kinase, zeta 104kDa; DAG kinase zeta; diglyceride kinase zeta; Diacylglyc ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DGKZ collected from DrugBank database. |
There is no record. |