Summary | |
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Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Microsome membrane Endoplasmic reticulum membrane Note=Associated with microsomal membranes. |
Domain |
PF00106 short chain dehydrogenase |
Function |
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. |
Biological Process |
GO:0001523 retinoid metabolic process GO:0002138 retinoic acid biosynthetic process GO:0006066 alcohol metabolic process GO:0006720 isoprenoid metabolic process GO:0006721 terpenoid metabolic process GO:0008202 steroid metabolic process GO:0008207 C21-steroid hormone metabolic process GO:0008209 androgen metabolic process GO:0008299 isoprenoid biosynthetic process GO:0010817 regulation of hormone levels GO:0016053 organic acid biosynthetic process GO:0016101 diterpenoid metabolic process GO:0016102 diterpenoid biosynthetic process GO:0016114 terpenoid biosynthetic process GO:0034308 primary alcohol metabolic process GO:0034754 cellular hormone metabolic process GO:0042180 cellular ketone metabolic process GO:0042445 hormone metabolic process GO:0042448 progesterone metabolic process GO:0042572 retinol metabolic process GO:0042573 retinoic acid metabolic process GO:0042904 9-cis-retinoic acid biosynthetic process GO:0042905 9-cis-retinoic acid metabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process GO:1901615 organic hydroxy compound metabolic process |
Molecular Function |
GO:0004022 alcohol dehydrogenase (NAD) activity GO:0004745 retinol dehydrogenase activity GO:0016229 steroid dehydrogenase activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016853 isomerase activity GO:0016854 racemase and epimerase activity GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0047035 testosterone dehydrogenase (NAD+) activity |
Cellular Component |
GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane |
KEGG |
hsa00830 Retinol metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5365859: RA biosynthesis pathway R-HSA-162582: Signal Transduction R-HSA-5362517: Signaling by Retinoic Acid R-HSA-2453902: The canonical retinoid cycle in rods (twilight vision) R-HSA-2187338: Visual phototransduction |
Summary | |
---|---|
Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DHRS9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DHRS9 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DHRS9 in various data sets.
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Points in the above scatter plot represent the mutation difference of DHRS9 in various data sets.
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Summary | |
---|---|
Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DHRS9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DHRS9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DHRS9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DHRS9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DHRS9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DHRS9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DHRS9 |
Name | dehydrogenase/reductase (SDR family) member 9 |
Aliases | RDHL; 3alpha-HSD; RETSDR8; RDH15; SDR9C4; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxyste ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DHRS9 collected from DrugBank database. |
There is no record. |