Summary | |
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Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF00008 EGF-like domain PF12661 Human growth factor-like EGF |
Function |
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0001756 somitogenesis GO:0003002 regionalization GO:0007219 Notch signaling pathway GO:0007386 compartment pattern specification GO:0007389 pattern specification process GO:0007498 mesoderm development GO:0009952 anterior/posterior pattern specification GO:0010721 negative regulation of cell development GO:0035282 segmentation GO:0048339 paraxial mesoderm development GO:0050768 negative regulation of neurogenesis GO:0051961 negative regulation of nervous system development GO:0060485 mesenchyme development GO:0061053 somite development |
Molecular Function |
GO:0005112 Notch binding |
Cellular Component | - |
KEGG |
hsa04330 Notch signaling pathway |
Reactome | - |
Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DLL3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DLL3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DLL3 in various data sets.
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Points in the above scatter plot represent the mutation difference of DLL3 in various data sets.
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Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DLL3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DLL3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DLL3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DLL3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DLL3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DLL3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DLL3 |
Name | delta-like 3 (Drosophila) |
Aliases | SCDO1; delta (Drosophila)-like 3; delta3; drosophila Delta homolog 3; Delta-like protein 3 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DLL3 collected from DrugBank database. |
There is no record. |