Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF01414 Delta serrate ligand PF00008 EGF-like domain PF07657 N terminus of Notch ligand |
Function |
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). |
Biological Process |
GO:0001525 angiogenesis GO:0001569 patterning of blood vessels GO:0001654 eye development GO:0001667 ameboidal-type cell migration GO:0001763 morphogenesis of a branching structure GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001937 negative regulation of endothelial cell proliferation GO:0001974 blood vessel remodeling GO:0002011 morphogenesis of an epithelial sheet GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002521 leukocyte differentiation GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003013 circulatory system process GO:0003158 endothelium development GO:0003159 morphogenesis of an endothelium GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003209 cardiac atrium morphogenesis GO:0003222 ventricular trabecula myocardium morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003230 cardiac atrium development GO:0003231 cardiac ventricle development GO:0003344 pericardium morphogenesis GO:0003407 neural retina development GO:0007159 leukocyte cell-cell adhesion GO:0007219 Notch signaling pathway GO:0007220 Notch receptor processing GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0007601 visual perception GO:0008015 blood circulation GO:0008593 regulation of Notch signaling pathway GO:0009953 dorsal/ventral pattern formation GO:0010594 regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0014706 striated muscle tissue development GO:0016525 negative regulation of angiogenesis GO:0021510 spinal cord development GO:0021511 spinal cord patterning GO:0021513 spinal cord dorsal/ventral patterning GO:0021514 ventral spinal cord interneuron differentiation GO:0021515 cell differentiation in spinal cord GO:0021517 ventral spinal cord development GO:0021953 central nervous system neuron differentiation GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030336 negative regulation of cell migration GO:0035239 tube morphogenesis GO:0035904 aorta development GO:0035907 dorsal aorta development GO:0035909 aorta morphogenesis GO:0035912 dorsal aorta morphogenesis GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0040013 negative regulation of locomotion GO:0042110 T cell activation GO:0043010 camera-type eye development GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045165 cell fate commitment GO:0045746 negative regulation of Notch signaling pathway GO:0045747 positive regulation of Notch signaling pathway GO:0045765 regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0048644 muscle organ morphogenesis GO:0048663 neuron fate commitment GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048771 tissue remodeling GO:0048844 artery morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050953 sensory perception of light stimulus GO:0051271 negative regulation of cellular component movement GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060039 pericardium development GO:0060041 retina development in camera-type eye GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0060562 epithelial tube morphogenesis GO:0060579 ventral spinal cord interneuron fate commitment GO:0060581 cell fate commitment involved in pattern specification GO:0060840 artery development GO:0061074 regulation of neural retina development GO:0061138 morphogenesis of a branching epithelium GO:0061154 endothelial tube morphogenesis GO:0061311 cell surface receptor signaling pathway involved in heart development GO:0061314 Notch signaling involved in heart development GO:0061351 neural precursor cell proliferation GO:0061383 trabecula morphogenesis GO:0061384 heart trabecula morphogenesis GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0071774 response to fibroblast growth factor GO:0072554 blood vessel lumenization GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1902866 regulation of retina development in camera-type eye GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903670 regulation of sprouting angiogenesis GO:1903671 negative regulation of sprouting angiogenesis GO:2000146 negative regulation of cell motility GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000181 negative regulation of blood vessel morphogenesis |
Molecular Function |
GO:0005112 Notch binding |
Cellular Component | - |
KEGG |
hsa04330 Notch signaling pathway |
Reactome |
R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2691232: Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2660826: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1 R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2979096: NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-156988: Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2691230: Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-2660825: Signaling by NOTCH1 t(7;9)(NOTCH1 R-HSA-1980145: Signaling by NOTCH2 R-HSA-1980148: Signaling by NOTCH3 R-HSA-1980150: Signaling by NOTCH4 |
Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DLL4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DLL4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DLL4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DLL4 in various data sets.
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Points in the above scatter plot represent the mutation difference of DLL4 in various data sets.
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Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DLL4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DLL4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DLL4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DLL4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DLL4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DLL4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DLL4 |
Name | delta-like 4 (Drosophila) |
Aliases | delta-like 4 homolog (Drosophila); hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 prot ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DLL4 collected from DrugBank database. |
There is no record. |