Summary | |
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Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton, cilium axoneme. |
Domain |
PF07728 AAA domain (dynein-related subfamily) PF12774 Hydrolytic ATP binding site of dynein motor region D1 PF12780 P-loop containing dynein motor region D4 PF12781 ATP-binding dynein motor region D5 PF08385 Dynein heavy chain PF08393 Dynein heavy chain PF03028 Dynein heavy chain and region D6 of dynein motor PF12777 Microtubule-binding stalk of dynein motor |
Function |
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. |
Biological Process |
GO:0007018 microtubule-based movement GO:0007283 spermatogenesis GO:0048232 male gamete generation |
Molecular Function |
GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0016887 ATPase activity |
Cellular Component |
GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0005929 cilium GO:0005930 axoneme GO:0030286 dynein complex GO:0044441 ciliary part GO:0097014 ciliary plasm |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DNAH9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DNAH9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DNAH9 in various data sets.
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Points in the above scatter plot represent the mutation difference of DNAH9 in various data sets.
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Summary | |
---|---|
Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DNAH9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DNAH9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DNAH9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DNAH9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DNAH9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DNAH9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DNAH9 |
Name | dynein, axonemal, heavy chain 9 |
Aliases | Dnahc9; KIAA0357; HL20; HL-20; DYH9; DNAH17L; dynein, axonemal, heavy polypeptide 17-like; dynein, axonemal, ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DNAH9 collected from DrugBank database. |
There is no record. |