TISIDB

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Lipid-anchor Melanosome Cell membrane Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Domain	PF00226 DnaJ domain
Function	Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0001505 regulation of neurotransmitter levels GO:0006836 neurotransmitter transport GO:0006887 exocytosis GO:0007269 neurotransmitter secretion GO:0016079 synaptic vesicle exocytosis GO:0017156 calcium ion regulated exocytosis GO:0023061 signal release GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0045055 regulated exocytosis GO:0048489 synaptic vesicle transport GO:0051402 neuron apoptotic process GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0070997 neuron death GO:0097479 synaptic vesicle localization GO:0097480 establishment of synaptic vesicle localization GO:0099003 vesicle-mediated transport in synapse GO:0099504 synaptic vesicle cycle GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death
Molecular Function	GO:0001948 glycoprotein binding GO:0043008 ATP-dependent protein binding
Cellular Component	GO:0005765 lysosomal membrane GO:0008021 synaptic vesicle GO:0030133 transport vesicle GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030424 axon GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0033267 axon part GO:0042470 melanosome GO:0043195 terminal bouton GO:0043679 axon terminus GO:0044306 neuron projection terminus GO:0048770 pigment granule GO:0060198 clathrin-sculpted vesicle GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0070382 exocytic vesicle GO:0098793 presynapse GO:0098852 lytic vacuole membrane GO:0099503 secretory vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04141 Protein processing in endoplasmic reticulum
Reactome	R-HSA-888590: GABA synthesis, release, reuptake and degradation R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-112316: Neuronal System R-HSA-112310: Neurotransmitter Release Cycle R-HSA-6798695: Neutrophil degranulation R-HSA-112315: Transmission across Chemical Synapses

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DNAJC5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of DNAJC5 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	STARS Score: 3.65; FDR: 0.041	Resistant to T cell-mediated killing
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of DNAJC5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.046	0.83
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.104	0.963
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.008	0.996
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.102	0.766
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.108	0.954
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.371	0.88
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.234	0.567
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.229	0.9
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.281	0.887
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.598	0.683
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.974	0.651
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.013	0.829

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of DNAJC5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	9.1	7.7	1.4	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	16.7	0	16.7	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DNAJC5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DNAJC5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DNAJC5. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DNAJC5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DNAJC5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DNAJC5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DNAJC5
Name	DnaJ (Hsp40) homolog, subfamily C, member 5
Aliases	FLJ00118; FLJ13070; DNAJC5A; CLN4; ceroid-lipofuscinosis, neuronal 4 (Kufs disease); CLN4B; CSPA; mir-941-2; ......
Chromosomal Location	20q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DNAJC5 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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