Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). |
Domain |
PF00008 EGF-like domain PF12661 Human growth factor-like EGF |
Function |
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). |
Biological Process |
GO:0001764 neuron migration GO:0007219 Notch signaling pathway GO:0007220 Notch receptor processing GO:0007416 synapse assembly GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0010001 glial cell differentiation GO:0014706 striated muscle tissue development GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0042063 gliogenesis GO:0042692 muscle cell differentiation GO:0048741 skeletal muscle fiber development GO:0048747 muscle fiber development GO:0050808 synapse organization GO:0051146 striated muscle cell differentiation GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development |
Molecular Function |
GO:0005112 Notch binding GO:0030276 clathrin binding |
Cellular Component |
GO:0005769 early endosome GO:0030425 dendrite GO:0043025 neuronal cell body GO:0044297 cell body |
KEGG | - |
Reactome |
R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 |
Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DNER and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DNER and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DNER in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DNER in various data sets.
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Points in the above scatter plot represent the mutation difference of DNER in various data sets.
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Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DNER. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DNER. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DNER. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DNER. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DNER expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DNER and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DNER |
Name | delta/notch-like EGF repeat containing |
Aliases | UNQ26; bet; H_NH0150O02.1; WUGSC:H_NH0150O02.1; delta-notch-like EGF repeat-containing transmembrane; Delta ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DNER collected from DrugBank database. |
There is no record. |