Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF01426 BAH domain PF06464 DMAP1-binding Domain PF00145 C-5 cytosine-specific DNA methylase PF12047 Cytosine specific DNA methyltransferase replication foci domain PF02008 CXXC zinc finger domain |
Function |
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). |
Biological Process |
GO:0001101 response to acid chemical GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0006479 protein methylation GO:0007265 Ras protein signal transduction GO:0008213 protein alkylation GO:0010216 maintenance of DNA methylation GO:0016458 gene silencing GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031062 positive regulation of histone methylation GO:0031935 regulation of chromatin silencing GO:0031937 positive regulation of chromatin silencing GO:0032259 methylation GO:0032776 DNA methylation on cytosine GO:0034968 histone lysine methylation GO:0040029 regulation of gene expression, epigenetic GO:0043200 response to amino acid GO:0043414 macromolecule methylation GO:0044728 DNA methylation or demethylation GO:0045814 negative regulation of gene expression, epigenetic GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051567 histone H3-K9 methylation GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051571 positive regulation of histone H3-K4 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0060968 regulation of gene silencing GO:0061647 histone H3-K9 modification GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071417 cellular response to organonitrogen compound GO:0090116 C-5 methylation of cytosine GO:0090308 regulation of methylation-dependent chromatin silencing GO:0090309 positive regulation of methylation-dependent chromatin silencing GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization GO:1905269 positive regulation of chromatin organization |
Molecular Function |
GO:0003682 chromatin binding GO:0003886 DNA (cytosine-5-)-methyltransferase activity GO:0008168 methyltransferase activity GO:0008327 methyl-CpG binding GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0009008 DNA-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:1990841 promoter-specific chromatin binding |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0000792 heterochromatin GO:0005657 replication fork GO:0005721 pericentric heterochromatin GO:0098687 chromosomal region |
KEGG |
hsa00270 Cysteine and methionine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5334118: DNA methylation R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-212300: PRC2 methylates histones and DNA |
Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DNMT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DNMT1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DNMT1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DNMT1 in various data sets.
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Points in the above scatter plot represent the mutation difference of DNMT1 in various data sets.
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Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DNMT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DNMT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DNMT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DNMT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DNMT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DNMT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DNMT1 |
Name | DNA (cytosine-5-)-methyltransferase 1 |
Aliases | MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DNMT1 collected from DrugBank database. |
Details on drugs targeting DNMT1.
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