Summary | |
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Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Cell projection, dendritic spine |
Domain |
PF06920 Dock homology region 2 PF14429 C2 domain in Dock180 and Zizimin proteins PF11878 Domain of unknown function (DUF3398) PF00169 PH domain |
Function |
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. |
Biological Process | - |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-109582: Hemostasis |
Summary | |
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Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DOCK10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DOCK10 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DOCK10 in various data sets.
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Points in the above scatter plot represent the mutation difference of DOCK10 in various data sets.
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Summary | |
---|---|
Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DOCK10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DOCK10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DOCK10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DOCK10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DOCK10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DOCK10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DOCK10 |
Name | dedicator of cytokinesis 10 |
Aliases | ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ...... |
Chromosomal Location | 2q36.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DOCK10 collected from DrugBank database. |
There is no record. |