Browse DOCK10

Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Cell projection, dendritic spine
Domain PF06920 Dock homology region 2
PF14429 C2 domain in Dock180 and Zizimin proteins
PF11878 Domain of unknown function (DUF3398)
PF00169 PH domain
Function

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.

> Gene Ontology
 
Biological Process -
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-109582: Hemostasis
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DOCK10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DOCK10 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DOCK10 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0260.944
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5540.698
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3590.737
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0610.876
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.450.824
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4350.872
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3810.374
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3160.854
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4830.797
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.2840.318
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.0460.271
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1170.476
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DOCK10 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.19.1140.596
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.93.74.20.636
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DOCK10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DOCK10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DOCK10.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DOCK10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DOCK10 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DOCK10 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDOCK10
Namededicator of cytokinesis 10
Aliases ZIZ3; KIAA0694; zizimin3; DRIP2; Nbla10300; dopamine receptor interacting protein 2; Zizimin-3; Dedicator of ......
Chromosomal Location2q36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DOCK10 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.