Summary | |
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Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Domain |
PF07297 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) |
Function |
Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0006493 protein O-linked glycosylation GO:0006497 protein lipidation GO:0006505 GPI anchor metabolic process GO:0006506 GPI anchor biosynthetic process GO:0006643 membrane lipid metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006664 glycolipid metabolic process GO:0006720 isoprenoid metabolic process GO:0008654 phospholipid biosynthetic process GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009247 glycolipid biosynthetic process GO:0016093 polyprenol metabolic process GO:0016254 preassembly of GPI anchor in ER membrane GO:0018196 peptidyl-asparagine modification GO:0018279 protein N-linked glycosylation via asparagine GO:0019348 dolichol metabolic process GO:0031647 regulation of protein stability GO:0035268 protein mannosylation GO:0035269 protein O-linked mannosylation GO:0042157 lipoprotein metabolic process GO:0042158 lipoprotein biosynthetic process GO:0043413 macromolecule glycosylation GO:0045017 glycerolipid biosynthetic process GO:0046467 membrane lipid biosynthetic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0070085 glycosylation GO:0097502 mannosylation GO:1901615 organic hydroxy compound metabolic process GO:1903509 liposaccharide metabolic process |
Molecular Function |
GO:0000030 mannosyltransferase activity GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups |
Cellular Component |
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0031501 mannosyltransferase complex GO:0033185 dolichol-phosphate-mannose synthase complex |
KEGG |
hsa00510 N-Glycan biosynthesis hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-392499: Metabolism of proteins R-HSA-163125: Post-translational modification R-HSA-597592: Post-translational protein modification R-HSA-162699: Synthesis of dolichyl-phosphate mannose R-HSA-162710: Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-446219: Synthesis of substrates in N-glycan biosythesis |
Summary | |
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Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DPM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DPM2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DPM2 in various data sets.
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Points in the above scatter plot represent the mutation difference of DPM2 in various data sets.
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Summary | |
---|---|
Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DPM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DPM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DPM2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DPM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DPM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DPM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DPM2 |
Name | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Aliases | MGC21559; MGC111193; CDG1U; DPM synthase subunit 2; dolichol-phosphate mannose synthase subunit 2; Dolichol ...... |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DPM2 collected from DrugBank database. |
There is no record. |