Summary | |
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Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Dipeptidyl peptidase 4 soluble form: Secreted Note=Detected in the serum and the seminal fluid.; SUBCELLULAR LOCATION: Cell membrane Single-pass type II membrane protein. Apical cell membrane Single-pass type II membrane protein. Cell projection, invadopodium membrane Single-pass type II membrane protein. Cell projection, lamellipodium membrane Single-pass type II membrane protein. Cell junction Membrane raft Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). |
Domain |
PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region PF00326 Prolyl oligopeptidase family |
Function |
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
Biological Process |
GO:0001662 behavioral fear response GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0002209 behavioral defense response GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0007159 leukocyte cell-cell adhesion GO:0007626 locomotory behavior GO:0010631 epithelial cell migration GO:0010715 regulation of extracellular matrix disassembly GO:0010716 negative regulation of extracellular matrix disassembly GO:0019058 viral life cycle GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0030260 entry into host cell GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0033555 multicellular organismal response to stress GO:0033627 cell adhesion mediated by integrin GO:0033628 regulation of cell adhesion mediated by integrin GO:0033631 cell-cell adhesion mediated by integrin GO:0033632 regulation of cell-cell adhesion mediated by integrin GO:0035640 exploration behavior GO:0035641 locomotory exploration behavior GO:0036293 response to decreased oxygen levels GO:0036343 psychomotor behavior GO:0042110 T cell activation GO:0042596 fear response GO:0043062 extracellular structure organization GO:0043542 endothelial cell migration GO:0044409 entry into host GO:0044708 single-organism behavior GO:0045785 positive regulation of cell adhesion GO:0046718 viral entry into host cell GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0061744 motor behavior GO:0070482 response to oxygen levels GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0090130 tissue migration GO:0090132 epithelium migration GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903053 regulation of extracellular matrix organization GO:1903054 negative regulation of extracellular matrix organization |
Molecular Function |
GO:0001618 virus receptor activity GO:0002020 protease binding GO:0004175 endopeptidase activity GO:0004177 aminopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity GO:0008238 exopeptidase activity GO:0008239 dipeptidyl-peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0005765 lysosomal membrane GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0016324 apical plasma membrane GO:0030027 lamellipodium GO:0030055 cell-substrate junction GO:0030139 endocytic vesicle GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0031258 lamellipodium membrane GO:0045121 membrane raft GO:0045177 apical part of cell GO:0046581 intercellular canaliculus GO:0071437 invadopodium GO:0071438 invadopodium membrane GO:0098589 membrane region GO:0098852 lytic vacuole membrane GO:0098857 membrane microdomain |
KEGG |
hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-400508: Incretin synthesis, secretion, and inactivation R-HSA-392499: Metabolism of proteins R-HSA-2980736: Peptide hormone metabolism R-HSA-381771: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-400511: Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Summary | |
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Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DPP4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DPP4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DPP4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DPP4 in various data sets.
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Points in the above scatter plot represent the mutation difference of DPP4 in various data sets.
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Summary | |
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Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DPP4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DPP4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DPP4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DPP4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DPP4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DPP4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DPP4 |
Name | dipeptidyl-peptidase 4 |
Aliases | CD26; ADCP2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase co ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DPP4 collected from DrugBank database. |
Details on drugs targeting DPP4.
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