Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF14047 Dppa2/4 conserved region PF14049 Dppa2/4 conserved region in higher vertebrates |
Function |
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. |
Biological Process |
GO:0006479 protein methylation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0019827 stem cell population maintenance GO:0030323 respiratory tube development GO:0030324 lung development GO:0031056 regulation of histone modification GO:0031060 regulation of histone methylation GO:0032259 methylation GO:0043414 macromolecule methylation GO:0060484 lung-associated mesenchyme development GO:0060485 mesenchyme development GO:0060541 respiratory system development GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0098727 maintenance of cell number GO:1902275 regulation of chromatin organization GO:2000648 positive regulation of stem cell proliferation |
Molecular Function |
GO:0003682 chromatin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DPPA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DPPA2 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of DPPA2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DPPA2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of DPPA2 in various data sets.
|
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DPPA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DPPA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DPPA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DPPA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DPPA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DPPA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DPPA2 |
Name | developmental pluripotency associated 2 |
Aliases | PESCRG1; CT100; cancer/testis antigen 100; ECAT15-2; embryonic stem cell (ESC) associated transcript 15-2; p ...... |
Chromosomal Location | 3q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DPPA2 collected from DrugBank database. |
There is no record. |