TISIDB

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Isoform Short: Secreted ; SUBCELLULAR LOCATION: Isoform Long: Cell membrane Single-pass type I membrane protein Cell projection, axon Cell junction, synapse Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
Domain	PF00041 Fibronectin type III domain PF07679 Immunoglobulin I-set domain
Function	Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0001558 regulation of cell growth GO:0001654 eye development GO:0001754 eye photoreceptor cell differentiation GO:0003407 neural retina development GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007162 negative regulation of cell adhesion GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007416 synapse assembly GO:0007423 sensory organ development GO:0007626 locomotory behavior GO:0008037 cell recognition GO:0008038 neuron recognition GO:0008361 regulation of cell size GO:0009791 post-embryonic development GO:0009886 post-embryonic animal morphogenesis GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010842 retina layer formation GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016049 cell growth GO:0016358 dendrite development GO:0022604 regulation of cell morphogenesis GO:0030307 positive regulation of cell growth GO:0030516 regulation of axon extension GO:0031346 positive regulation of cell projection organization GO:0032103 positive regulation of response to external stimulus GO:0032535 regulation of cellular component size GO:0040017 positive regulation of locomotion GO:0043010 camera-type eye development GO:0045666 positive regulation of neuron differentiation GO:0045773 positive regulation of axon extension GO:0045927 positive regulation of growth GO:0046530 photoreceptor cell differentiation GO:0048588 developmental cell growth GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048813 dendrite morphogenesis GO:0048841 regulation of axon extension involved in axon guidance GO:0048842 positive regulation of axon extension involved in axon guidance GO:0048846 axon extension involved in axon guidance GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050808 synapse organization GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051272 positive regulation of cellular component movement GO:0051962 positive regulation of nervous system development GO:0060041 retina development in camera-type eye GO:0060042 retina morphogenesis in camera-type eye GO:0060060 post-embryonic retina morphogenesis in camera-type eye GO:0060219 camera-type eye photoreceptor cell differentiation GO:0060560 developmental growth involved in morphogenesis GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0070593 dendrite self-avoidance GO:0090066 regulation of anatomical structure size GO:0090596 sensory organ morphogenesis GO:0097485 neuron projection guidance GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1902284 neuron projection extension involved in neuron projection guidance GO:1902667 regulation of axon guidance GO:1902669 positive regulation of axon guidance GO:1990138 neuron projection extension
Molecular Function	-
Cellular Component	GO:0030424 axon GO:0030426 growth cone GO:0030427 site of polarized growth

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1500931: Cell-Cell communication R-HSA-376172: DSCAM interactions

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DSCAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of DSCAM in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of DSCAM in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.103	0.813
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.542	0.694
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.45	0.794
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0	1
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0	1
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0	1
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.156	0.716
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.156	0.808
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.093	0.772

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of DSCAM in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	25.9	21.9	4	0.79
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	21.4	-21.4	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	25.9	22	3.9	0.785
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	52.4	35.3	17.1	0.342
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	37.5	33.3	4.2	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	61.5	36.4	25.1	0.414
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	31.6	7.4	24.2	0.0304
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	31.8	7.7	24.1	0.21
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	31.2	7.1	24.1	0.175
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DSCAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DSCAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DSCAM. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DSCAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DSCAM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DSCAM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DSCAM
Name	Down syndrome cell adhesion molecule
Aliases	CHD2-42; CHD2-52
Chromosomal Location	21q22.2-q22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DSCAM collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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