Browse DSCC1

Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF09724 Uncharacterized conserved protein (DUF2036)
Function

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000819 sister chromatid segregation
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006275 regulation of DNA replication
GO:0006473 protein acetylation
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0034086 maintenance of sister chromatid cohesion
GO:0034088 maintenance of mitotic sister chromatid cohesion
GO:0034421 post-translational protein acetylation
GO:0043543 protein acylation
GO:0043687 post-translational protein modification
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0071897 DNA biosynthetic process
GO:0090329 regulation of DNA-dependent DNA replication
GO:0098813 nuclear chromosome segregation
GO:1900262 regulation of DNA-directed DNA polymerase activity
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
GO:2000278 regulation of DNA biosynthetic process
GO:2000573 positive regulation of DNA biosynthetic process
Molecular Function GO:0003689 DNA clamp loader activity
GO:0008094 DNA-dependent ATPase activity
GO:0016887 ATPase activity
GO:0033170 protein-DNA loading ATPase activity
GO:0042623 ATPase activity, coupled
GO:0043142 single-stranded DNA-dependent ATPase activity
Cellular Component GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0031390 Ctf18 RFC-like complex
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DSCC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DSCC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.70; FDR: 0.00545 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DSCC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4410.0505
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4890.633
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4150.65
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1640.644
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0360.974
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4120.781
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0410.914
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5710.622
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.640.583
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4150.521
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8130.376
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3360.00299
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DSCC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DSCC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DSCC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DSCC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DSCC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DSCC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DSCC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDSCC1
NameDNA replication and sister chromatid cohesion 1
Aliases DCC1; hDCC1; MGC5528; defective in sister chromatid cohesion homolog 1 (S. cerevisiae); defective in sister ......
Chromosomal Location8q24.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DSCC1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.