Summary | |
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Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF16332 Domain of unknown function (DUF4962) |
Function |
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006029 proteoglycan metabolic process GO:0006790 sulfur compound metabolic process GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0015012 heparan sulfate proteoglycan biosynthetic process GO:0030166 proteoglycan biosynthetic process GO:0030201 heparan sulfate proteoglycan metabolic process GO:0030203 glycosaminoglycan metabolic process GO:0030204 chondroitin sulfate metabolic process GO:0030205 dermatan sulfate metabolic process GO:0030206 chondroitin sulfate biosynthetic process GO:0030208 dermatan sulfate biosynthetic process GO:0044272 sulfur compound biosynthetic process GO:0050650 chondroitin sulfate proteoglycan biosynthetic process GO:0050651 dermatan sulfate proteoglycan biosynthetic process GO:0050654 chondroitin sulfate proteoglycan metabolic process GO:0050655 dermatan sulfate proteoglycan metabolic process GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0016853 isomerase activity GO:0016854 racemase and epimerase activity GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0047757 chondroitin-glucuronate 5-epimerase activity |
Cellular Component | - |
KEGG |
hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate hsa01100 Metabolic pathways |
Reactome |
R-HSA-1793185: Chondroitin sulfate/dermatan sulfate metabolism R-HSA-2022923: Dermatan sulfate biosynthesis R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DSE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DSE and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DSE in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DSE in various data sets.
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Points in the above scatter plot represent the mutation difference of DSE in various data sets.
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Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DSE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DSE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DSE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DSE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DSE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DSE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DSE |
Name | dermatan sulfate epimerase |
Aliases | DSEPI; SART2; squamous cell carcinoma antigen recognized by T cells 2; DSEPPI; EDSMC2; SART-2; DS epimerase; ...... |
Chromosomal Location | 6q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DSE collected from DrugBank database. |
There is no record. |