Summary | |
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Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Early endosome membrane Peripheral membrane protein Cytoplasmic side Lysosome membrane Peripheral membrane protein Cytoplasmic side Note=Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272). Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM (PubMed:24790097). A minor proportion localizes to lysosomes (PubMed:24790097). |
Domain | - |
Function |
E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788). |
Biological Process |
GO:0000209 protein polyubiquitination GO:0006302 double-strand break repair GO:0006513 protein monoubiquitination GO:0010390 histone monoubiquitination GO:0016570 histone modification GO:0016574 histone ubiquitination |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0042393 histone binding |
Cellular Component | - |
KEGG |
hsa04330 Notch signaling pathway |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System |
Summary | |
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Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DTX3L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DTX3L in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DTX3L in various data sets.
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Points in the above scatter plot represent the mutation difference of DTX3L in various data sets.
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Summary | |
---|---|
Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DTX3L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DTX3L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DTX3L. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DTX3L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DTX3L expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DTX3L and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DTX3L |
Name | deltex 3 like, E3 ubiquitin ligase |
Aliases | BBAP; rhysin 2; deltex 3-like (Drosophila); B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin-2; ...... |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DTX3L collected from DrugBank database. |
There is no record. |