Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF00782 Dual specificity phosphatase |
Function |
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). |
Biological Process |
GO:0000188 inactivation of MAPK activity GO:0001933 negative regulation of protein phosphorylation GO:0002250 adaptive immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002707 negative regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002710 negative regulation of T cell mediated immunity GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0006469 negative regulation of protein kinase activity GO:0006470 protein dephosphorylation GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007254 JNK cascade GO:0016311 dephosphorylation GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0031098 stress-activated protein kinase signaling cascade GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033673 negative regulation of kinase activity GO:0035335 peptidyl-tyrosine dephosphorylation GO:0042110 T cell activation GO:0042326 negative regulation of phosphorylation GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043410 positive regulation of MAPK cascade GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0050777 negative regulation of immune response GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050854 regulation of antigen receptor-mediated signaling pathway GO:0050856 regulation of T cell receptor signaling pathway GO:0050858 negative regulation of antigen receptor-mediated signaling pathway GO:0050860 negative regulation of T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051348 negative regulation of transferase activity GO:0051403 stress-activated MAPK cascade GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071593 lymphocyte aggregation GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:1902532 negative regulation of intracellular signal transduction GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DUSP22 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DUSP22 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DUSP22 in various data sets.
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Points in the above scatter plot represent the mutation difference of DUSP22 in various data sets.
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Summary | |
---|---|
Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DUSP22. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DUSP22. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DUSP22. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DUSP22. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DUSP22 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DUSP22 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DUSP22 |
Name | dual specificity phosphatase 22 |
Aliases | JSP1; JKAP; VHX; JSP-1; LMW-DSP2; LMWDSP2; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; MAP ...... |
Chromosomal Location | 6p25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DUSP22 collected from DrugBank database. |
There is no record. |