Summary | |
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Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton |
Domain |
PF01221 Dynein light chain type 1 |
Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). |
Biological Process |
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0006839 mitochondrial transport GO:0006888 ER to Golgi vesicle-mediated transport GO:0006914 autophagy GO:0007006 mitochondrial membrane organization GO:0008037 cell recognition GO:0008038 neuron recognition GO:0008039 synaptic target recognition GO:0008637 apoptotic mitochondrial changes GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016236 macroautophagy GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0035794 positive regulation of mitochondrial membrane permeability GO:0046902 regulation of mitochondrial membrane permeability GO:0048002 antigen processing and presentation of peptide antigen GO:0048193 Golgi vesicle transport GO:0051204 protein insertion into mitochondrial membrane GO:0051205 protein insertion into membrane GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090559 regulation of membrane permeability GO:0097345 mitochondrial outer membrane permeabilization GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway |
Molecular Function |
GO:0003774 motor activity |
Cellular Component |
GO:0005813 centrosome GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0005929 cilium GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0030286 dynein complex GO:0044441 ciliary part GO:0072372 primary cilium GO:0097542 ciliary tip |
KEGG |
hsa04962 Vasopressin-regulated water reabsorption |
Reactome |
R-HSA-114452: Activation of BH3-only proteins R-HSA-139910: Activation of BMF and translocation to mitochondria R-HSA-1280218: Adaptive Immune System R-HSA-109581: Apoptosis R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6811436: COPI-independent Golgi-to-ER retrograde traffic R-HSA-6807878: COPI-mediated anterograde transport R-HSA-2262752: Cellular responses to stress R-HSA-5617833: Cilium Assembly R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-168256: Immune System R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5620924: Intraflagellar transport R-HSA-109606: Intrinsic Pathway for Apoptosis R-HSA-2132295: MHC class II antigen presentation R-HSA-1632852: Macroautophagy R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-597592: Post-translational protein modification R-HSA-5357801: Programmed Cell Death R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DYNLL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DYNLL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DYNLL2 in various data sets.
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There is no record. |
Summary | |
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Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DYNLL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DYNLL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DYNLL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DYNLL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DYNLL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DYNLL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DYNLL2 |
Name | dynein, light chain, LC8-type 2 |
Aliases | MGC17810; DNCL1B; RSPH22; radial spoke 22 homolog (Chlamydomonas); 8 kDa dynein light chain b; DLC8b; radial ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DYNLL2 collected from DrugBank database. |
There is no record. |