Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Nucleus speckle |
Domain |
PF00069 Protein kinase domain |
Function |
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000380 alternative mRNA splicing, via spliceosome GO:0000381 regulation of alternative mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0006476 protein deacetylation GO:0007623 circadian rhythm GO:0008380 RNA splicing GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0018212 peptidyl-tyrosine modification GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0033119 negative regulation of RNA splicing GO:0035601 protein deacylation GO:0042770 signal transduction in response to DNA damage GO:0043484 regulation of RNA splicing GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0046777 protein autophosphorylation GO:0048024 regulation of mRNA splicing, via spliceosome GO:0048025 negative regulation of mRNA splicing, via spliceosome GO:0048511 rhythmic process GO:0050684 regulation of mRNA processing GO:0050686 negative regulation of mRNA processing GO:0072331 signal transduction by p53 class mediator GO:0090311 regulation of protein deacetylation GO:0090312 positive regulation of protein deacetylation GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902532 negative regulation of intracellular signal transduction GO:1903311 regulation of mRNA metabolic process GO:1903312 negative regulation of mRNA metabolic process GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004712 protein serine/threonine/tyrosine kinase activity GO:0004713 protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0043621 protein self-association GO:0048156 tau protein binding |
Cellular Component |
GO:0016604 nuclear body GO:0016607 nuclear speck |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-1538133: G0 and Early G1 R-HSA-453279: Mitotic G1-G1/S phases |
Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DYRK1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DYRK1A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DYRK1A in various data sets.
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Points in the above scatter plot represent the mutation difference of DYRK1A in various data sets.
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Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DYRK1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DYRK1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DYRK1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DYRK1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DYRK1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DYRK1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DYRK1A |
Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
Aliases | DYRK1; DYRK; MNBH; HP86; MNB; MRD7; MNB/DYRK protein kinase; dual specificity YAK1-related kinase; hMNB; mnb ...... |
Chromosomal Location | 21q22.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DYRK1A collected from DrugBank database. |
Details on drugs targeting DYRK1A.
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