Summary | |
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Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF16421 E2F transcription factor CC-MB domain PF02319 E2F/DP family winged-helix DNA-binding domain |
Function |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0097193 intrinsic apoptotic signaling pathway GO:1904019 epithelial cell apoptotic process GO:1990086 lens fiber cell apoptotic process |
Molecular Function |
GO:0001047 core promoter binding GO:0008134 transcription factor binding |
Cellular Component |
GO:0005667 transcription factor complex |
KEGG |
hsa04110 Cell cycle |
Reactome |
R-HSA-68867: Assembly of the pre-replicative complex R-HSA-69298: Association of licensing factors with the pre-replicative complex R-HSA-68689: CDC6 association with the ORC R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-69231: Cyclin D associated events in G1 R-HSA-69306: DNA Replication R-HSA-69002: DNA Replication Pre-Initiation R-HSA-69236: G1 Phase R-HSA-68874: M/G1 Transition R-HSA-453279: Mitotic G1-G1/S phases R-HSA-2559585: Oncogene Induced Senescence R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-69304: Regulation of DNA replication |
Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between E2F2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of E2F2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of E2F2 in various data sets.
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Points in the above scatter plot represent the mutation difference of E2F2 in various data sets.
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Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of E2F2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of E2F2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by E2F2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of E2F2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of E2F2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | E2F2 |
Name | E2F transcription factor 2 |
Aliases | E2F-2; Transcription factor E2F2 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between E2F2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |