Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF16422 Transcription factor COE1 DNA-binding domain PF16423 Transcription factor COE1 helix-loop-helix domain PF01833 IPT/TIG domain |
Function |
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). |
Biological Process |
GO:0001709 cell fate determination GO:0035561 regulation of chromatin binding GO:0035563 positive regulation of chromatin binding GO:0045165 cell fate commitment GO:0045444 fat cell differentiation GO:0050873 brown fat cell differentiation GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0060612 adipose tissue development GO:0061448 connective tissue development |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EBF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EBF2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EBF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of EBF2 in various data sets.
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Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EBF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EBF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EBF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EBF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EBF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EBF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | EBF2 |
Name | early B-cell factor 2 |
Aliases | FLJ11500; COE2; EBF-2; O/E-3; OE-3; Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; metencephalon-mesencephalnon-o ...... |
Chromosomal Location | 8p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EBF2 collected from DrugBank database. |
There is no record. |