Summary | |
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Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00531 Death domain |
Function |
Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. |
Biological Process |
GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0071356 cellular response to tumor necrosis factor |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EDARADD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EDARADD in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EDARADD in various data sets.
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Points in the above scatter plot represent the mutation difference of EDARADD in various data sets.
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Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EDARADD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EDARADD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EDARADD. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EDARADD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EDARADD expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EDARADD and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EDARADD |
Name | EDAR-associated death domain |
Aliases | ECTD11A; ECTD11B; EDAR-associated death domain protein; crinkled homolog; ectodysplasia A receptor associate ...... |
Chromosomal Location | 1q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EDARADD collected from DrugBank database. |
There is no record. |