Summary | |
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Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
Biological Process |
GO:0001525 angiogenesis GO:0001569 patterning of blood vessels GO:0001666 response to hypoxia GO:0001701 in utero embryonic development GO:0001763 morphogenesis of a branching structure GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007190 activation of adenylate cyclase activity GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007389 pattern specification process GO:0007507 heart development GO:0007585 respiratory gaseous exchange GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010863 positive regulation of phospholipase C activity GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014820 tonic smooth muscle contraction GO:0014824 artery smooth muscle contraction GO:0014829 vascular smooth muscle contraction GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030800 negative regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030803 negative regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030809 negative regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030815 negative regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030818 negative regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0035150 regulation of tube size GO:0035239 tube morphogenesis GO:0036293 response to decreased oxygen levels GO:0042310 vasoconstriction GO:0045761 regulation of adenylate cyclase activity GO:0045762 positive regulation of adenylate cyclase activity GO:0045980 negative regulation of nucleotide metabolic process GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0048483 autonomic nervous system development GO:0048484 enteric nervous system development GO:0048514 blood vessel morphogenesis GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050880 regulation of blood vessel size GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0052652 cyclic purine nucleotide metabolic process GO:0055074 calcium ion homeostasis GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060485 mesenchyme development GO:0060562 epithelial tube morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0070482 response to oxygen levels GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072522 purine-containing compound biosynthetic process GO:0086100 endothelin receptor signaling pathway GO:0090066 regulation of anatomical structure size GO:1900274 regulation of phospholipase C activity GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900372 negative regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process |
Molecular Function |
GO:0001653 peptide receptor activity GO:0004435 phosphatidylinositol phospholipase C activity GO:0004620 phospholipase activity GO:0004629 phospholipase C activity GO:0004962 endothelin receptor activity GO:0008081 phosphoric diester hydrolase activity GO:0008528 G-protein coupled peptide receptor activity GO:0016298 lipase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component | - |
KEGG |
hsa04020 Calcium signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04270 Vascular smooth muscle contraction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EDNRA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EDNRA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EDNRA in various data sets.
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Points in the above scatter plot represent the mutation difference of EDNRA in various data sets.
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Summary | |
---|---|
Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EDNRA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EDNRA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EDNRA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EDNRA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EDNRA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EDNRA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EDNRA |
Name | endothelin receptor type A |
Aliases | ET-A; ETA; ETA-R; ETAR; ETRA; MFDA; hET-AR; endothelin receptor subtype A; endothelin-1-specific receptor; E ...... |
Chromosomal Location | 4q31.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EDNRA collected from DrugBank database. |
Details on drugs targeting EDNRA.
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