Summary | |
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Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. |
Domain |
PF00679 Elongation factor G C-terminus PF03764 Elongation factor G PF00009 Elongation factor Tu GTP binding domain PF03144 Elongation factor Tu domain 2 |
Function |
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0001101 response to acid chemical GO:0002181 cytoplasmic translation GO:0002244 hematopoietic progenitor cell differentiation GO:0002931 response to ischemia GO:0003009 skeletal muscle contraction GO:0003012 muscle system process GO:0006414 translational elongation GO:0006417 regulation of translation GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0006979 response to oxidative stress GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0007568 aging GO:0007584 response to nutrient GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010608 posttranscriptional regulation of gene expression GO:0014009 glial cell proliferation GO:0014706 striated muscle tissue development GO:0017182 peptidyl-diphthamide metabolic process GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0018202 peptidyl-histidine modification GO:0031667 response to nutrient levels GO:0032355 response to estradiol GO:0033273 response to vitamin GO:0034248 regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034976 response to endoplasmic reticulum stress GO:0035914 skeletal muscle cell differentiation GO:0042063 gliogenesis GO:0042542 response to hydrogen peroxide GO:0045471 response to ethanol GO:0045727 positive regulation of translation GO:0050879 multicellular organismal movement GO:0050881 musculoskeletal movement GO:0051593 response to folic acid GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0097305 response to alcohol GO:1990089 response to nerve growth factor GO:1990090 cellular response to nerve growth factor stimulus GO:1990416 cellular response to brain-derived neurotrophic factor stimulus GO:2000765 regulation of cytoplasmic translation GO:2000767 positive regulation of cytoplasmic translation |
Molecular Function |
GO:0002039 p53 binding GO:0003746 translation elongation factor activity GO:0003779 actin binding GO:0003924 GTPase activity GO:0005525 GTP binding GO:0008097 5S rRNA binding GO:0008135 translation factor activity, RNA binding GO:0019001 guanyl nucleotide binding GO:0019843 rRNA binding GO:0032561 guanyl ribonucleotide binding GO:0043021 ribonucleoprotein complex binding GO:0043022 ribosome binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0051015 actin filament binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005840 ribosome GO:0005844 polysome GO:0005913 cell-cell adherens junction GO:0016234 inclusion body GO:0016235 aggresome GO:0042788 polysomal ribosome GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04152 AMPK signaling pathway hsa04921 Oxytocin signaling pathway |
Reactome |
R-HSA-1643685: Disease R-HSA-156842: Eukaryotic Translation Elongation R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-74160: Gene Expression R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-6798695: Neutrophil degranulation R-HSA-156902: Peptide chain elongation R-HSA-597592: Post-translational protein modification R-HSA-8876725: Protein methylation R-HSA-5358493: Synthesis of diphthamide-EEF2 R-HSA-72766: Translation R-HSA-5339562: Uptake and actions of bacterial toxins R-HSA-5336415: Uptake and function of diphtheria toxin |
Summary | |
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Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EEF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EEF2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EEF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of EEF2 in various data sets.
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Summary | |
---|---|
Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EEF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EEF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EEF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EEF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EEF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EEF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | EEF2 |
Name | eukaryotic translation elongation factor 2 |
Aliases | EEF-2; polypeptidyl-tRNA translocase; EF2; EF-2; Elongation factor 2 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EEF2 collected from DrugBank database. |
Details on drugs targeting EEF2.
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