Summary | |
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Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF00812 Ephrin |
Function |
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. ; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. |
Biological Process |
GO:0001525 angiogenesis GO:0001655 urogenital system development GO:0001667 ameboidal-type cell migration GO:0001822 kidney development GO:0001945 lymph vessel development GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0007159 leukocyte cell-cell adhesion GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007507 heart development GO:0007517 muscle organ development GO:0010631 epithelial cell migration GO:0010837 regulation of keratinocyte proliferation GO:0010839 negative regulation of keratinocyte proliferation GO:0014706 striated muscle tissue development GO:0016202 regulation of striated muscle tissue development GO:0019058 viral life cycle GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030260 entry into host cell GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0035051 cardiocyte differentiation GO:0035239 tube morphogenesis GO:0035904 aorta development GO:0035909 aorta morphogenesis GO:0042110 T cell activation GO:0042692 muscle cell differentiation GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0043616 keratinocyte proliferation GO:0044409 entry into host GO:0045785 positive regulation of cell adhesion GO:0045844 positive regulation of striated muscle tissue development GO:0046718 viral entry into host cell GO:0048013 ephrin receptor signaling pathway GO:0048514 blood vessel morphogenesis GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048738 cardiac muscle tissue development GO:0048844 artery morphogenesis GO:0048845 venous blood vessel morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050920 regulation of chemotaxis GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0055007 cardiac muscle cell differentiation GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0060537 muscle tissue development GO:0060562 epithelial tube morphogenesis GO:0060840 artery development GO:0060841 venous blood vessel development GO:0061564 axon development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0072001 renal system development GO:0072073 kidney epithelium development GO:0072176 nephric duct development GO:0072178 nephric duct morphogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097485 neuron projection guidance GO:1901342 regulation of vasculature development GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903847 regulation of aorta morphogenesis GO:1903849 positive regulation of aorta morphogenesis GO:1904018 positive regulation of vasculature development GO:1905207 regulation of cardiocyte differentiation GO:1905209 positive regulation of cardiocyte differentiation GO:2000725 regulation of cardiac muscle cell differentiation GO:2000727 positive regulation of cardiac muscle cell differentiation |
Molecular Function |
GO:0001618 virus receptor activity GO:0046875 ephrin receptor binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG |
hsa04360 Axon guidance |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928665: EPH-ephrin mediated repulsion of cells R-HSA-3928662: EPHB-mediated forward signaling R-HSA-3928664: Ephrin signaling |
Summary | |
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Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EFNB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EFNB2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EFNB2 in various data sets.
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Points in the above scatter plot represent the mutation difference of EFNB2 in various data sets.
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Summary | |
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Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EFNB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EFNB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EFNB2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EFNB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EFNB2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EFNB2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EFNB2 |
Name | ephrin-B2 |
Aliases | LERK5; Htk-L; HTKL; MGC126226; MGC126227; MGC126228; HTK ligand; ligand of eph-related kinase 5; eph-related ...... |
Chromosomal Location | 13q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EFNB2 collected from DrugBank database. |
There is no record. |