Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasm, cytosol Note=Palmitoylation anchors the protein to the plasma membrane (PubMed:23229899, PubMed:25380825). A small amount is observed in the cytosol (PubMed:25380825). |
Domain | - |
Function |
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). |
Biological Process |
GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0007009 plasma membrane organization GO:0030258 lipid modification GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:1990778 protein localization to cell periphery |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EFR3B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EFR3B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EFR3B in various data sets.
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Points in the above scatter plot represent the mutation difference of EFR3B in various data sets.
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Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EFR3B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EFR3B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EFR3B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EFR3B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EFR3B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | EFR3B |
Name | EFR3 homolog B |
Aliases | FLJ37871; KIAA0953; EFR3 homolog B (S. cerevisiae); Protein EFR3 homolog B |
Chromosomal Location | 2p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EFR3B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |