Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space |
Domain |
PF07974 EGF-like domain PF07645 Calcium-binding EGF domain PF07546 EMI domain |
Function |
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. |
Biological Process |
GO:0001525 angiogenesis GO:0001570 vasculogenesis GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0007219 Notch signaling pathway GO:0008593 regulation of Notch signaling pathway GO:0045746 negative regulation of Notch signaling pathway GO:0048514 blood vessel morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EGFL7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between EGFL7 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EGFL7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EGFL7 in various data sets.
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Points in the above scatter plot represent the mutation difference of EGFL7 in various data sets.
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Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EGFL7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EGFL7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EGFL7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EGFL7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EGFL7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EGFL7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EGFL7 |
Name | EGF-like-domain, multiple 7 |
Aliases | ZNEU1; VE-STATIN; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epi ...... |
Chromosomal Location | 9q34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EGFL7 collected from DrugBank database. |
There is no record. |