Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome Endosome membrane. Nucleus Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). ; SUBCELLULAR LOCATION: Isoform 2: Secreted. |
Domain |
PF00757 Furin-like cysteine rich region PF14843 Growth factor receptor domain IV PF07714 Protein tyrosine kinase PF01030 Receptor L domain |
Function |
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance (By similarity). ; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. |
Biological Process |
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000082 G1/S transition of mitotic cell cycle GO:0000186 activation of MAPKK activity GO:0001101 response to acid chemical GO:0001503 ossification GO:0001558 regulation of cell growth GO:0001654 eye development GO:0001701 in utero embryonic development GO:0001889 liver development GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001894 tissue homeostasis GO:0001942 hair follicle development GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006282 regulation of DNA repair GO:0006417 regulation of translation GO:0006606 protein import into nucleus GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006720 isoprenoid metabolic process GO:0006721 terpenoid metabolic process GO:0006801 superoxide metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006913 nucleocytoplasmic transport GO:0006970 response to osmotic stress GO:0006979 response to oxidative stress GO:0007173 epidermal growth factor receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007270 neuron-neuron synaptic transmission GO:0007346 regulation of mitotic cell cycle GO:0007423 sensory organ development GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007494 midgut development GO:0007584 response to nutrient GO:0007611 learning or memory GO:0007623 circadian rhythm GO:0008015 blood circulation GO:0008544 epidermis development GO:0009306 protein secretion GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009612 response to mechanical stimulus GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009914 hormone transport GO:0009991 response to extracellular stimulus GO:0010001 glial cell differentiation GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010608 posttranscriptional regulation of gene expression GO:0010817 regulation of hormone levels GO:0010863 positive regulation of phospholipase C activity GO:0010960 magnesium ion homeostasis GO:0014002 astrocyte development GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0015833 peptide transport GO:0016049 cell growth GO:0016101 diterpenoid metabolic process GO:0016441 posttranscriptional gene silencing GO:0016458 gene silencing GO:0017038 protein import GO:0017148 negative regulation of translation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019229 regulation of vasoconstriction GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0021537 telencephalon development GO:0021543 pallium development GO:0021782 glial cell development GO:0021795 cerebral cortex cell migration GO:0021885 forebrain cell migration GO:0021987 cerebral cortex development GO:0022029 telencephalon cell migration GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0022612 gland morphogenesis GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030258 lipid modification GO:0030307 positive regulation of cell growth GO:0030323 respiratory tube development GO:0030324 lung development GO:0030335 positive regulation of cell migration GO:0030900 forebrain development GO:0031047 gene silencing by RNA GO:0031050 dsRNA fragmentation GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031349 positive regulation of defense response GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032355 response to estradiol GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032429 regulation of phospholipase A2 activity GO:0032430 positive regulation of phospholipase A2 activity GO:0032431 activation of phospholipase A2 activity GO:0032768 regulation of monooxygenase activity GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032928 regulation of superoxide anion generation GO:0032930 positive regulation of superoxide anion generation GO:0033002 muscle cell proliferation GO:0033157 regulation of intracellular protein transport GO:0033273 response to vitamin GO:0033590 response to cobalamin GO:0033594 response to hydroxyisoflavone GO:0033674 positive regulation of kinase activity GO:0034103 regulation of tissue remodeling GO:0034105 positive regulation of tissue remodeling GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034504 protein localization to nucleus GO:0035150 regulation of tube size GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0035196 production of miRNAs involved in gene silencing by miRNA GO:0035239 tube morphogenesis GO:0035249 synaptic transmission, glutamatergic GO:0035272 exocrine system development GO:0035411 catenin import into nucleus GO:0035412 regulation of catenin import into nucleus GO:0035413 positive regulation of catenin import into nucleus GO:0035690 cellular response to drug GO:0038127 ERBB signaling pathway GO:0038128 ERBB2 signaling pathway GO:0040017 positive regulation of locomotion GO:0040029 regulation of gene expression, epigenetic GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0042063 gliogenesis GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042303 molting cycle GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042310 vasoconstriction GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042493 response to drug GO:0042554 superoxide anion generation GO:0042633 hair cycle GO:0042698 ovulation cycle GO:0042743 hydrogen peroxide metabolic process GO:0042886 amide transport GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling GO:0043010 camera-type eye development GO:0043200 response to amino acid GO:0043331 response to dsRNA GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043491 protein kinase B signaling GO:0043586 tongue development GO:0043588 skin development GO:0044057 regulation of system process GO:0044708 single-organism behavior GO:0044744 protein targeting to nucleus GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045124 regulation of bone resorption GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045453 bone resorption GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045739 positive regulation of DNA repair GO:0045740 positive regulation of DNA replication GO:0045780 positive regulation of bone resorption GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0045907 positive regulation of vasoconstriction GO:0045909 positive regulation of vasodilation GO:0045927 positive regulation of growth GO:0045930 negative regulation of mitotic cell cycle GO:0046209 nitric oxide metabolic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046777 protein autophosphorylation GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046834 lipid phosphorylation GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0046852 positive regulation of bone remodeling GO:0046854 phosphatidylinositol phosphorylation GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048143 astrocyte activation GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048511 rhythmic process GO:0048545 response to steroid hormone GO:0048546 digestive tract morphogenesis GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048708 astrocyte differentiation GO:0048732 gland development GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050804 modulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0050880 regulation of blood vessel size GO:0050890 cognition GO:0050999 regulation of nitric-oxide synthase activity GO:0051047 positive regulation of secretion GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051205 protein insertion into membrane GO:0051222 positive regulation of protein transport GO:0051272 positive regulation of cellular component movement GO:0051341 regulation of oxidoreductase activity GO:0051384 response to glucocorticoid GO:0051592 response to calcium ion GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0051966 regulation of synaptic transmission, glutamatergic GO:0051968 positive regulation of synaptic transmission, glutamatergic GO:0055123 digestive system development GO:0060147 regulation of posttranscriptional gene silencing GO:0060148 positive regulation of posttranscriptional gene silencing GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060249 anatomical structure homeostasis GO:0060541 respiratory system development GO:0060571 morphogenesis of an epithelial fold GO:0060964 regulation of gene silencing by miRNA GO:0060966 regulation of gene silencing by RNA GO:0060968 regulation of gene silencing GO:0061008 hepaticobiliary system development GO:0061029 eyelid development in camera-type eye GO:0061458 reproductive system development GO:0070141 response to UV-A GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070459 prolactin secretion GO:0070849 response to epidermal growth factor GO:0070918 production of small RNA involved in gene silencing by RNA GO:0070920 regulation of production of small RNA involved in gene silencing by RNA GO:0071214 cellular response to abiotic stimulus GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071260 cellular response to mechanical stimulus GO:0071359 cellular response to dsRNA GO:0071364 cellular response to epidermal growth factor stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0071548 response to dexamethasone GO:0071549 cellular response to dexamethasone stimulus GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072507 divalent inorganic cation homeostasis GO:0072593 reactive oxygen species metabolic process GO:0072657 protein localization to membrane GO:0080184 response to phenylpropanoid GO:0090066 regulation of anatomical structure size GO:0090087 regulation of peptide transport GO:0090150 establishment of protein localization to membrane GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:0090316 positive regulation of intracellular protein transport GO:0090322 regulation of superoxide metabolic process GO:0097421 liver regeneration GO:0098773 skin epidermis development GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1900274 regulation of phospholipase C activity GO:1901184 regulation of ERBB signaling pathway GO:1901185 negative regulation of ERBB signaling pathway GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1901987 regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1902593 single-organism nuclear import GO:1902722 positive regulation of prolactin secretion GO:1902806 regulation of cell cycle G1/S phase transition GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903532 positive regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903829 positive regulation of cellular protein localization GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904031 positive regulation of cyclin-dependent protein kinase activity GO:1904407 positive regulation of nitric oxide metabolic process GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization GO:1990267 response to transition metal nanoparticle GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000147 positive regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000637 positive regulation of gene silencing by miRNA GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0001948 glycoprotein binding GO:0003682 chromatin binding GO:0003779 actin binding GO:0004674 protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0004709 MAP kinase kinase kinase activity GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0004716 receptor signaling protein tyrosine kinase activity GO:0005006 epidermal growth factor-activated receptor activity GO:0005057 receptor signaling protein activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005178 integrin binding GO:0005516 calmodulin binding GO:0019199 transmembrane receptor protein kinase activity GO:0019838 growth factor binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0030235 nitric-oxide synthase regulator activity GO:0031625 ubiquitin protein ligase binding GO:0035004 phosphatidylinositol 3-kinase activity GO:0042562 hormone binding GO:0044389 ubiquitin-like protein ligase binding GO:0045296 cadherin binding GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046982 protein heterodimerization activity GO:0048408 epidermal growth factor binding GO:0050839 cell adhesion molecule binding GO:0051015 actin filament binding GO:0052813 phosphatidylinositol bisphosphate kinase activity GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005635 nuclear envelope GO:0005769 early endosome GO:0005770 late endosome GO:0005771 multivesicular body GO:0005775 vacuolar lumen GO:0005905 clathrin-coated pit GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0010008 endosome membrane GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0030055 cell-substrate junction GO:0030117 membrane coat GO:0030118 clathrin coat GO:0030119 AP-type membrane coat adaptor complex GO:0030120 vesicle coat GO:0030122 AP-2 adaptor complex GO:0030125 clathrin vesicle coat GO:0030128 clathrin coat of endocytic vesicle GO:0030131 clathrin adaptor complex GO:0030132 clathrin coat of coated pit GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0031901 early endosome membrane GO:0031965 nuclear membrane GO:0031983 vesicle lumen GO:0043235 receptor complex GO:0044440 endosomal part GO:0045121 membrane raft GO:0045177 apical part of cell GO:0045334 clathrin-coated endocytic vesicle GO:0048475 coated membrane GO:0070435 Shc-EGFR complex GO:0097487 multivesicular body, internal vesicle GO:0097489 multivesicular body, internal vesicle lumen GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04010 MAPK signaling pathway hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04020 Calcium signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04144 Endocytosis hsa04151 PI3K-Akt signaling pathway hsa04320 Dorso-ventral axis formation hsa04510 Focal adhesion hsa04520 Adherens junction hsa04540 Gap junction hsa04810 Regulation of actin cytoskeleton hsa04912 GnRH signaling pathway hsa04915 Estrogen signaling pathway hsa04921 Oxytocin signaling pathway |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5637810: Constitutive Signaling by EGFRvIII R-HSA-1236382: Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-8863795: Downregulation of ERBB2 signaling R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2179392: EGFR Transactivation by Gastrin R-HSA-182971: EGFR downregulation R-HSA-212718: EGFR interacts with phospholipase C-gamma R-HSA-8847993: ERBB2 Activates PTK6 Signaling R-HSA-6785631: ERBB2 Regulates Cell Motility R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-1963640: GRB2 events in ERBB2 signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-5638303: Inhibition of Signaling by Overexpressed EGFR R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-373760: L1CAM interactions R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-199991: Membrane Trafficking R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-1963642: PI3K events in ERBB2 signaling R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-1251932: PLCG1 events in ERBB2 signaling R-HSA-8857538: PTK6 promotes HIF1A stabilization R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-180336: SHC1 events in EGFR signaling R-HSA-1250196: SHC1 events in ERBB2 signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-445144: Signal transduction by L1 R-HSA-177929: Signaling by EGFR R-HSA-1643713: Signaling by EGFR in Cancer R-HSA-5637812: Signaling by EGFRvIII in Cancer R-HSA-1227986: Signaling by ERBB2 R-HSA-1236394: Signaling by ERBB4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-5637815: Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5638302: Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-186797: Signaling by PDGF R-HSA-8848021: Signaling by PTK6 R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EGFR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between EGFR and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EGFR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EGFR in various data sets.
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Points in the above scatter plot represent the mutation difference of EGFR in various data sets.
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Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EGFR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EGFR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EGFR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EGFR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EGFR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EGFR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | EGFR |
Name | epidermal growth factor receptor |
Aliases | ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; ...... |
Chromosomal Location | 7p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EGFR collected from DrugBank database. |
Details on drugs targeting EGFR.
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