Summary | |
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Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus membrane Multi-pass membrane protein Cytoplasm Endoplasmic reticulum membrane Multi-pass membrane protein |
Domain | - |
Function |
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). |
Biological Process |
GO:0001558 regulation of cell growth GO:0006914 autophagy GO:0016049 cell growth GO:0016236 macroautophagy GO:0030308 negative regulation of cell growth GO:0045926 negative regulation of growth |
Molecular Function | - |
Cellular Component |
GO:0005635 nuclear envelope GO:0031965 nuclear membrane |
KEGG |
hsa04115 p53 signaling pathway |
Reactome | - |
Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EI24 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EI24 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EI24 in various data sets.
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Points in the above scatter plot represent the mutation difference of EI24 in various data sets.
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Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EI24. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EI24. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EI24. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EI24. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EI24 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EI24 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EI24 |
Name | etoposide induced 2.4 |
Aliases | TP53I8; EPG4; ectopic P-granules autophagy protein 4 homolog (C. elegans); etoposide induced 2.4 mRNA; ectop ...... |
Chromosomal Location | 11q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EI24 collected from DrugBank database. |
There is no record. |