Browse EIF2S1

Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, Stress granule Note=Colocalizes with NANOS3 in the stress granules.
Domain PF07541 Eukaryotic translation initiation factor 2 alpha subunit
PF00575 S1 RNA binding domain
Function

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

> Gene Ontology
 
Biological Process GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0007568 aging
GO:0009266 response to temperature stimulus
GO:0009267 cellular response to starvation
GO:0009314 response to radiation
GO:0009408 response to heat
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010042 response to manganese ion
GO:0010608 posttranscriptional regulation of gene expression
GO:0017148 negative regulation of translation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0032055 negative regulation of translation in response to stress
GO:0032057 negative regulation of translational initiation in response to stress
GO:0034198 cellular response to amino acid starvation
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0034605 cellular response to heat
GO:0034620 cellular response to unfolded protein
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036499 PERK-mediated unfolded protein response
GO:0042594 response to starvation
GO:0043555 regulation of translation in response to stress
GO:0043558 regulation of translational initiation in response to stress
GO:0045947 negative regulation of translational initiation
GO:0046777 protein autophosphorylation
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0070997 neuron death
GO:0071214 cellular response to abiotic stimulus
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071287 cellular response to manganese ion
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0071496 cellular response to external stimulus
GO:0097050 type B pancreatic cell apoptotic process
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1905097 regulation of guanyl-nucleotide exchange factor activity
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:1990267 response to transition metal nanoparticle
GO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:2000674 regulation of type B pancreatic cell apoptotic process
GO:2000676 positive regulation of type B pancreatic cell apoptotic process
Molecular Function GO:0003743 translation initiation factor activity
GO:0008135 translation factor activity, RNA binding
GO:0043021 ribonucleoprotein complex binding
GO:0043022 ribosome binding
Cellular Component GO:0005840 ribosome
GO:0005844 polysome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0010494 cytoplasmic stress granule
GO:0033290 eukaryotic 48S preinitiation complex
GO:0035770 ribonucleoprotein granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043614 multi-eIF complex
GO:0044207 translation initiation ternary complex
GO:0070993 translation preinitiation complex
GO:0097386 glial cell projection
GO:0097449 astrocyte projection
GO:0097450 astrocyte end-foot
GO:0097451 glial limiting end-foot
> KEGG and Reactome Pathway
 
KEGG hsa03013 RNA transport
hsa04140 Regulation of autophagy
hsa04141 Protein processing in endoplasmic reticulum
hsa04210 Apoptosis
Reactome R-HSA-157279: 3' -UTR-mediated translational regulation
R-HSA-382556: ABC-family proteins mediated transport
R-HSA-72662: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72737: Cap-dependent Translation Initiation
R-HSA-72613: Eukaryotic Translation Initiation
R-HSA-72695: Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72706: GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-74160: Gene Expression
R-HSA-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-392499: Metabolism of proteins
R-HSA-381042: PERK regulates gene expression
R-HSA-72731: Recycling of eIF2
R-HSA-72702: Ribosomal scanning and start codon recognition
R-HSA-72766: Translation
R-HSA-72649: Translation initiation complex formation
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-381119: Unfolded Protein Response (UPR)
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between EIF2S1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of EIF2S1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.61 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of EIF2S1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1660.542
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6850.739
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2130.887
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3610.478
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2330.878
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1190.588
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0260.95
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0670.972
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0540.979
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2050.91
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0110.997
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0450.468
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of EIF2S1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EIF2S1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EIF2S1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EIF2S1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EIF2S1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of EIF2S1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between EIF2S1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolEIF2S1
Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases EIF-2alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); EIF-2; eIF-2-alpha; eukary ......
Chromosomal Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting EIF2S1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.