Browse EIF3L

Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF10255 RNA polymerase I-associated factor PAF67
Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). ; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

> Gene Ontology
 
Biological Process GO:0001731 formation of translation preinitiation complex
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0010608 posttranscriptional regulation of gene expression
GO:0019058 viral life cycle
GO:0019080 viral gene expression
GO:0019081 viral translation
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0034248 regulation of cellular amide metabolic process
GO:0044033 multi-organism metabolic process
GO:0071826 ribonucleoprotein complex subunit organization
GO:0075525 viral translational termination-reinitiation
Molecular Function GO:0003743 translation initiation factor activity
GO:0008135 translation factor activity, RNA binding
Cellular Component GO:0001650 fibrillar center
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0044452 nucleolar part
GO:0070993 translation preinitiation complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-157279: 3' -UTR-mediated translational regulation
R-HSA-72662: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72737: Cap-dependent Translation Initiation
R-HSA-72613: Eukaryotic Translation Initiation
R-HSA-72689: Formation of a pool of free 40S subunits
R-HSA-72695: Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72706: GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-74160: Gene Expression
R-HSA-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-392499: Metabolism of proteins
R-HSA-72702: Ribosomal scanning and start codon recognition
R-HSA-72766: Translation
R-HSA-72649: Translation initiation complex formation
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between EIF3L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of EIF3L in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.6 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of EIF3L in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1340.509
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0040.999
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2240.93
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3630.59
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3980.863
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3320.665
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0450.93
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1290.958
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2440.929
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.240.926
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1910.961
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1310.0488
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of EIF3L in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EIF3L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EIF3L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EIF3L.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EIF3L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of EIF3L expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between EIF3L and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolEIF3L
Nameeukaryotic translation initiation factor 3, subunit L
Aliases HSPC021; HSPC025; EIF3S11; EIF3S6IP; EIF3EIP; eukaryotic translation initiation factor 3, subunit 6 interact ......
Chromosomal Location22q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting EIF3L collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.