Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. |
Domain |
PF00178 Ets-domain PF02198 Sterile alpha motif (SAM)/Pointed domain |
Function |
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). |
Biological Process |
GO:0001701 in utero embryonic development GO:0001824 blastocyst development GO:0008544 epidermis development GO:0022612 gland morphogenesis GO:0030198 extracellular matrix organization GO:0030879 mammary gland development GO:0043062 extracellular structure organization GO:0048732 gland development GO:0048771 tissue remodeling GO:0060056 mammary gland involution GO:0060443 mammary gland morphogenesis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003713 transcription coactivator activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ELF3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ELF3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ELF3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ELF3 in various data sets.
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Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELF3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELF3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELF3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELF3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ELF3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ELF3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ELF3 |
Name | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Aliases | ESE-1; ERT; ESX; E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific); E74-l ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ELF3 collected from DrugBank database. |
There is no record. |