Summary | |
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Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, PML body Note=Accumulation into PML nuclear bodies is mediated by PML. |
Domain |
PF12310 Transcription factor protein N terminal PF00178 Ets-domain |
Function |
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. |
Biological Process |
GO:0001787 natural killer cell proliferation GO:0001866 NK T cell proliferation GO:0007159 leukocyte cell-cell adhesion GO:0030101 natural killer cell activation GO:0032943 mononuclear cell proliferation GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0046631 alpha-beta T cell activation GO:0046633 alpha-beta T cell proliferation GO:0046651 lymphocyte proliferation GO:0051132 NK T cell activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0071593 lymphocyte aggregation |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component |
GO:0005635 nuclear envelope GO:0016604 nuclear body GO:0016605 PML body GO:0031965 nuclear membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ELF4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ELF4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ELF4 in various data sets.
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Points in the above scatter plot represent the mutation difference of ELF4 in various data sets.
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Summary | |
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Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELF4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELF4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELF4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELF4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ELF4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ELF4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ELF4 |
Name | E74-like factor 4 (ets domain transcription factor) |
Aliases | ELFR; myeloid Elf-1-like factor; E74-like factor 4; ETS-related transcription factor Elf-4 |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ELF4 collected from DrugBank database. |
There is no record. |