Summary | |
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Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00178 Ets-domain PF02198 Sterile alpha motif (SAM)/Pointed domain |
Function |
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. ; FUNCTION: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. |
Biological Process |
GO:0001704 formation of primary germ layer GO:0001705 ectoderm formation GO:0001712 ectodermal cell fate commitment GO:0007369 gastrulation GO:0007398 ectoderm development GO:0010668 ectodermal cell differentiation GO:0019827 stem cell population maintenance GO:0030879 mammary gland development GO:0035019 somatic stem cell population maintenance GO:0045165 cell fate commitment GO:0048732 gland development GO:0060644 mammary gland epithelial cell differentiation GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0061180 mammary gland epithelium development GO:0098727 maintenance of cell number |
Molecular Function |
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG |
hsa04917 Prolactin signaling pathway |
Reactome | - |
Summary | |
---|---|
Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ELF5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ELF5 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ELF5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ELF5 in various data sets.
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Points in the above scatter plot represent the mutation difference of ELF5 in various data sets.
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Summary | |
---|---|
Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELF5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELF5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELF5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELF5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ELF5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ELF5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ELF5 |
Name | E74-like factor 5 (ets domain transcription factor) |
Aliases | ESE2; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2; ESE-2; ...... |
Chromosomal Location | 11p13-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ELF5 collected from DrugBank database. |
There is no record. |