Browse ELMO1

Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Domain PF11841 Domain of unknown function (DUF3361)
PF04727 ELMO/CED-12 family
PF16457 Pleckstrin homology domain
Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

> Gene Ontology
 
Biological Process GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0002697 regulation of immune effector process
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002831 regulation of response to biotic stimulus
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0007265 Ras protein signal transduction
GO:0009615 response to virus
GO:0010324 membrane invagination
GO:0016601 Rac protein signal transduction
GO:0038093 Fc receptor signaling pathway
GO:0038094 Fc-gamma receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043900 regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050688 regulation of defense response to virus
GO:0050690 regulation of defense response to virus by virus
GO:0050792 regulation of viral process
GO:0051607 defense response to virus
GO:0098542 defense response to other organism
GO:0099024 plasma membrane invagination
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
GO:0017124 SH3 domain binding
Cellular Component GO:0032045 guanyl-nucleotide exchange factor complex
> KEGG and Reactome Pathway
 
KEGG hsa04062 Chemokine signaling pathway
Reactome R-HSA-1643685: Disease
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-162906: HIV Infection
R-HSA-162909: Host Interactions of HIV factors
R-HSA-168256: Immune System
R-HSA-5663205: Infectious disease
R-HSA-168249: Innate Immune System
R-HSA-164944: Nef and signal transduction
R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-HSA-162582: Signal Transduction
R-HSA-8848021: Signaling by PTK6
R-HSA-194138: Signaling by VEGF
R-HSA-164952: The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-4420097: VEGFA-VEGFR2 Pathway
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ELMO1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ELMO1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ELMO1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.220.569
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3820.689
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1080.897
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.210.522
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3580.859
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0230.993
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4350.336
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6450.581
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1940.882
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0120.415
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3690.467
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.270.0645
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ELMO1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277322.24.118.10.011
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275922.25.117.10.0245
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.517.6-8.10.64
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311027.3-27.30.0815
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.2013.20.0705
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELMO1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELMO1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELMO1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELMO1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ELMO1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ELMO1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolELMO1
Nameengulfment and cell motility 1
Aliases KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ......
Chromosomal Location7p14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ELMO1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.