Summary | |
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Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK. |
Domain |
PF11841 Domain of unknown function (DUF3361) PF04727 ELMO/CED-12 family PF16457 Pleckstrin homology domain |
Function |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
Biological Process |
GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002697 regulation of immune effector process GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002831 regulation of response to biotic stimulus GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0007265 Ras protein signal transduction GO:0009615 response to virus GO:0010324 membrane invagination GO:0016601 Rac protein signal transduction GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0050688 regulation of defense response to virus GO:0050690 regulation of defense response to virus by virus GO:0050792 regulation of viral process GO:0051607 defense response to virus GO:0098542 defense response to other organism GO:0099024 plasma membrane invagination |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0017124 SH3 domain binding |
Cellular Component |
GO:0032045 guanyl-nucleotide exchange factor complex |
KEGG |
hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-1643685: Disease R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-162906: HIV Infection R-HSA-162909: Host Interactions of HIV factors R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168249: Innate Immune System R-HSA-164944: Nef and signal transduction R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-162582: Signal Transduction R-HSA-8848021: Signaling by PTK6 R-HSA-194138: Signaling by VEGF R-HSA-164952: The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-4420097: VEGFA-VEGFR2 Pathway |
Summary | |
---|---|
Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ELMO1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ELMO1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ELMO1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ELMO1 in various data sets.
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Summary | |
---|---|
Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELMO1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELMO1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELMO1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELMO1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ELMO1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ELMO1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ELMO1 |
Name | engulfment and cell motility 1 |
Aliases | KIAA0281; ELMO-1; engulfment and cell motility 1 (ced-12 homolog, C. elegans); ced-12 homolog 1; Protein ced ...... |
Chromosomal Location | 7p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ELMO1 collected from DrugBank database. |
There is no record. |