Summary | |
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Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix Note=Extracellular matrix of elastic fibers. |
Domain | - |
Function |
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). |
Biological Process |
GO:0003013 circulatory system process GO:0007585 respiratory gaseous exchange GO:0008015 blood circulation GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0043062 extracellular structure organization |
Molecular Function |
GO:0005201 extracellular matrix structural constituent |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0044420 extracellular matrix component GO:0071953 elastic fiber |
KEGG |
hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-1566948: Elastic fibre formation R-HSA-1474244: Extracellular matrix organization |
Summary | |
---|---|
Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ELN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ELN in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ELN in various data sets.
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Points in the above scatter plot represent the mutation difference of ELN in various data sets.
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Summary | |
---|---|
Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ELN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ELN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ELN |
Name | elastin |
Aliases | SVAS; tropoelastin; supravalvular aortic stenosis; Williams-Beuren syndrome |
Chromosomal Location | 7q11.1-q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ELN collected from DrugBank database. |
Details on drugs targeting ELN.
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