Summary | |
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Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. |
Domain |
PF05625 PAXNEB protein |
Function |
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. |
Biological Process |
GO:0006354 DNA-templated transcription, elongation GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0043967 histone H4 acetylation |
Molecular Function |
GO:0000993 RNA polymerase II core binding GO:0001098 basal transcription machinery binding GO:0001099 basal RNA polymerase II transcription machinery binding GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0008607 phosphorylase kinase regulator activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0019207 kinase regulator activity GO:0019887 protein kinase regulator activity GO:0034212 peptide N-acetyltransferase activity GO:0043175 RNA polymerase core enzyme binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0070063 RNA polymerase binding |
Cellular Component |
GO:0000123 histone acetyltransferase complex GO:0008023 transcription elongation factor complex GO:0031248 protein acetyltransferase complex GO:0033588 Elongator holoenzyme complex GO:1902493 acetyltransferase complex |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones |
Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ELP4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ELP4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ELP4 in various data sets.
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Points in the above scatter plot represent the mutation difference of ELP4 in various data sets.
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Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELP4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELP4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELP4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELP4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ELP4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ELP4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ELP4 |
Name | elongator acetyltransferase complex subunit 4 |
Aliases | PAXNEB; C11orf19; chromosome 11 open reading frame 19; elongation protein 4 homolog (S. cerevisiae); PAX6NEB ...... |
Chromosomal Location | 11p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ELP4 collected from DrugBank database. |
There is no record. |