Summary | |
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Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. |
Domain | - |
Function |
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. |
Biological Process |
GO:0030335 positive regulation of cell migration GO:0040017 positive regulation of locomotion GO:0051272 positive regulation of cellular component movement GO:2000147 positive regulation of cell motility |
Molecular Function | - |
Cellular Component |
GO:0033588 Elongator holoenzyme complex |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones |
Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ELP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ELP5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ELP5 in various data sets.
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Points in the above scatter plot represent the mutation difference of ELP5 in various data sets.
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Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ELP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ELP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ELP5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ELP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ELP5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ELP5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ELP5 |
Name | elongator acetyltransferase complex subunit 5 |
Aliases | DERP6; dermal papilla derived protein 6; S-phase 2 protein; C17orf81; chromosome 17 open reading frame 81; H ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ELP5 collected from DrugBank database. |
There is no record. |