Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell membrane Cytoplasm, myofibril, sarcomere, M line Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.; SUBCELLULAR LOCATION: Isoform MBP-1: Nucleus. |
Domain |
PF00113 Enolase PF03952 Enolase |
Function |
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.; FUNCTION: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. |
Biological Process |
GO:0001558 regulation of cell growth GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006007 glucose catabolic process GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006734 NADH metabolic process GO:0006735 NADH regeneration GO:0006757 ATP generation from ADP GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009615 response to virus GO:0016049 cell growth GO:0016051 carbohydrate biosynthetic process GO:0016052 carbohydrate catabolic process GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0019320 hexose catabolic process GO:0019362 pyridine nucleotide metabolic process GO:0019674 NAD metabolic process GO:0030308 negative regulation of cell growth GO:0042278 purine nucleoside metabolic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0045926 negative regulation of growth GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046364 monosaccharide biosynthetic process GO:0046365 monosaccharide catabolic process GO:0046496 nicotinamide nucleotide metabolic process GO:0046939 nucleotide phosphorylation GO:0051186 cofactor metabolic process GO:0061615 glycolytic process through fructose-6-phosphate GO:0061620 glycolytic process through glucose-6-phosphate GO:0061621 canonical glycolysis GO:0061718 glucose catabolic process to pyruvate GO:0072524 pyridine-containing compound metabolic process GO:1901657 glycosyl compound metabolic process |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0016836 hydro-lyase activity GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0051020 GTPase binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0000015 phosphopyruvate hydratase complex GO:0005913 cell-cell adherens junction GO:0030016 myofibril GO:0030017 sarcomere GO:0031430 M band GO:0031672 A band GO:0043292 contractile fiber GO:0044445 cytosolic part GO:0044449 contractile fiber part |
KEGG |
hsa03018 RNA degradation hsa04066 HIF-1 signaling pathway hsa00010 Glycolysis / Gluconeogenesis hsa01100 Metabolic pathways hsa01200 Carbon metabolism hsa01230 Biosynthesis of amino acids |
Reactome |
R-HSA-70263: Gluconeogenesis R-HSA-70326: Glucose metabolism R-HSA-70171: Glycolysis R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ENO1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ENO1 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ENO1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ENO1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of ENO1 in various data sets.
|
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ENO1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ENO1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ENO1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ENO1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ENO1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ENO1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ENO1 |
Name | enolase 1, (alpha) |
Aliases | PPH; ENO1L1; MPB1; NNE; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enol ...... |
Chromosomal Location | 1p36.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ENO1 collected from DrugBank database. |
Details on drugs targeting ENO1.
|