Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Secreted, extracellular space Note=Extracellular and plasma membrane-associated. |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM |
Function |
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. |
Biological Process |
GO:0048511 rhythmic process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ENOX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ENOX1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ENOX1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ENOX1 in various data sets.
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Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ENOX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ENOX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ENOX1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ENOX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ENOX1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ENOX1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ENOX1 |
Name | ecto-NOX disulfide-thiol exchanger 1 |
Aliases | FLJ10094; PIG38; CNOX; cCNOX; bA64J21.1; candidate growth-related and time keeping constitutive hydroquinone ...... |
Chromosomal Location | 13q14.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ENOX1 collected from DrugBank database. |
There is no record. |