Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF01150 GDA1/CD39 (nucleoside phosphatase) family |
Function |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. |
Biological Process |
GO:0007596 blood coagulation GO:0007599 hemostasis GO:0050817 coagulation GO:0050878 regulation of body fluid levels |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa00230 Purine metabolism hsa00240 Pyrimidine metabolism |
Reactome |
R-HSA-1430728: Metabolism R-HSA-15869: Metabolism of nucleotides R-HSA-8850843: Phosphate bond hydrolysis by NTPDase proteins |
Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ENTPD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ENTPD1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ENTPD1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ENTPD1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ENTPD1 in various data sets.
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Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ENTPD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ENTPD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ENTPD1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ENTPD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ENTPD1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ENTPD1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ENTPD1 |
Name | ectonucleoside triphosphate diphosphohydrolase 1 |
Aliases | NTPDase-1; ATPDase; SPG64; CD39; CD39 antigen; NTPDase 1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ect ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ENTPD1 collected from DrugBank database. |
There is no record. |