Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00907 T-box PF16176 T-box transcription factor-associated |
Function |
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. |
Biological Process |
GO:0001701 in utero embryonic development GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0001707 mesoderm formation GO:0001708 cell fate specification GO:0001711 endodermal cell fate commitment GO:0001714 endodermal cell fate specification GO:0001824 blastocyst development GO:0001825 blastocyst formation GO:0001829 trophectodermal cell differentiation GO:0001837 epithelial to mesenchymal transition GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002521 leukocyte differentiation GO:0003002 regionalization GO:0007159 leukocyte cell-cell adhesion GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007492 endoderm development GO:0007498 mesoderm development GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0010002 cardioblast differentiation GO:0014706 striated muscle tissue development GO:0019827 stem cell population maintenance GO:0021537 telencephalon development GO:0021543 pallium development GO:0021772 olfactory bulb development GO:0021796 cerebral cortex regionalization GO:0021871 forebrain regionalization GO:0021895 cerebral cortex neuron differentiation GO:0021953 central nervous system neuron differentiation GO:0021978 telencephalon regionalization GO:0021987 cerebral cortex development GO:0021988 olfactory lobe development GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030900 forebrain development GO:0032609 interferon-gamma production GO:0035051 cardiocyte differentiation GO:0035914 skeletal muscle cell differentiation GO:0035987 endodermal cell differentiation GO:0036037 CD8-positive, alpha-beta T cell activation GO:0042110 T cell activation GO:0043374 CD8-positive, alpha-beta T cell differentiation GO:0045165 cell fate commitment GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0048332 mesoderm morphogenesis GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060706 cell differentiation involved in embryonic placenta development GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0060809 mesodermal to mesenchymal transition involved in gastrulation GO:0061458 reproductive system development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0098727 maintenance of cell number |
Molecular Function |
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0008134 transcription factor binding GO:0033613 activating transcription factor binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-2892245: POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-452723: Transcriptional regulation of pluripotent stem cells |
Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EOMES and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between EOMES and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EOMES in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EOMES in various data sets.
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Points in the above scatter plot represent the mutation difference of EOMES in various data sets.
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Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EOMES. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EOMES. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EOMES. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EOMES. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EOMES expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EOMES and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | EOMES |
Name | eomesodermin |
Aliases | TBR2; T-box brain2; eomesodermin (Xenopus laevis) homolog; T-box brain protein 2; TBR-2; T-brain-2; Eomesode ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EOMES collected from DrugBank database. |
There is no record. |