Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Lateral cell membrane Single-pass type I membrane protein Cell junction, tight junction Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. |
Domain |
PF00086 Thyroglobulin type-1 repeat |
Function |
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
Biological Process |
GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001822 kidney development GO:0001823 mesonephros development GO:0007162 negative regulation of cell adhesion GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0023019 signal transduction involved in regulation of gene expression GO:0040017 positive regulation of locomotion GO:0044331 cell-cell adhesion mediated by cadherin GO:0048863 stem cell differentiation GO:0051272 positive regulation of cellular component movement GO:0072001 renal system development GO:0072073 kidney epithelium development GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:2000047 regulation of cell-cell adhesion mediated by cadherin GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin GO:2000147 positive regulation of cell motility GO:2000648 positive regulation of stem cell proliferation |
Molecular Function |
GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005923 bicellular tight junction GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0016328 lateral plasma membrane GO:0043296 apical junction complex GO:0045177 apical part of cell GO:0070160 occluding junction |
KEGG | - |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis |
Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EPCAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between EPCAM and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EPCAM in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EPCAM in various data sets.
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Points in the above scatter plot represent the mutation difference of EPCAM in various data sets.
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Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EPCAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EPCAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EPCAM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EPCAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EPCAM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EPCAM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | EPCAM |
Name | epithelial cell adhesion molecule |
Aliases | Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; 323/A3; 17- ...... |
Chromosomal Location | 2p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EPCAM collected from DrugBank database. |
Details on drugs targeting EPCAM.
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